Results 171 to 180 of about 27,999 (384)
Advanced Science, EarlyView.Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen +12 more
wiley +1 more source
Suppression of haematopoiesis during therapy of chronic hepatitis C with different interferon mono and combination therapy regimens [PDF]
, 2005 M Schmid
openalex +1 more source
Advanced Science, EarlyView.A critical aspect of chromosomal remodeling in small molecule‐induced multilineage trans‐differentiation(iMT) is elucidated. A dynamic atlas spanning over 35 days profiles terminal trans‐differentiated cells, which reverted to a more youthful state. This study reveals parallels between iMT and other cell fate determination processes, emphasizing an ...
Weigao E +13 more
wiley +1 more source
Frontiers in Tropical DiseasesThe parasitic worm-derived immunomodulator, ES-62 rescues defective levels of IL-10-producing regulatory B cells (Bregs) and suppresses chronic Th1/Th17-driven inflammation to protect against joint destruction in the mouse collagen-induced arthritis (CIA)
Margaret M. Harnett +9 more
doaj +1 more source
Distinctive functions of methionine aminopeptidase II in embryonic haematopoiesis in zebrafish embryos [PDF]
, 2010 Oral presentationINTRODUCTION: Methionine aminopeptidase 2 (MetAP-2) is known to be the target of an anti-angiogenesis compound fumagillin and has been investigated for its robust expression in human cancers and its antiproliferative effects on ...
Chung, MIS +5 more
core
Advanced Science, EarlyView.This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu +38 more
wiley +1 more source
HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury
Advanced Science, EarlyView.Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou +7 more
wiley +1 more source
Mini review of metabolism in leukaemia: from complexity to the clinic
Frontiers in HematologyThe importance of metabolism to cancer has increasingly been recognised and this is particularly the case for leukaemia. This has opened the possibility of targeting dysregulated metabolism with the aim of increasing the effectiveness of current ...
Kevin M. Rattigan
doaj +1 more source
Bone morphogenetic protein 4 modulates c‐Kit expression and differentiation potential in murine embryonic aorta‐gonad‐mesonephros haematopoiesis in vitro [PDF]
, 2007 Caroline Marshall +3 more
openalex +1 more source
Advanced Science, EarlyView.Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao +11 more
wiley +1 more source