Results 171 to 180 of about 13,881 (340)

The embryonic origins of human haematopoiesis

open access: bronze, 2001
Caroline Marshall, Adrian J. Thrasher
openalex   +1 more source

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

open access: yesAdvanced Science, EarlyView.
DiffMC‐Gen, a dual‐diffusion model for 2D and 3D molecular generation, simultaneously optimizes multiple key objectives across the drug design process, enabling the generation of novel, target‐specific small‐molecule ligands with high therapeutic potential.
Yuwei Yang   +7 more
wiley   +1 more source

The Fine Mechanics of Haematopoiesis

open access: yesScientia, 2020
Qianze Dong, Chen Zhao
openaire   +1 more source

Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study develops lipid nanoparticles (LNPs) combining cationic and ionizable lipids for efficient cytosolic protein delivery. Optimized LNPs deliver functional proteins, including antibodies, enzymes, and Cas9, with high serum stability and albumin‐mediated endocytosis.
Lanfang Ren   +6 more
wiley   +1 more source

Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction

open access: yesEBioMedicine, 2022
Sheng-yi Wang   +15 more
semanticscholar   +1 more source

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

open access: yesAdvanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian   +5 more
wiley   +1 more source

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