Results 231 to 240 of about 13,881 (340)

Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression

Animal Models and Experimental Medicine, EarlyView.
We found that NLRC4 inflammasome was activated in microglia releasing IL6 and TNF‐α to impair the hippocampal neural stem cells (NSCs) self‐proliferation. ApoD contributed to activating NLRC4 inflammasome in microglia. Targeting the ApoD provides beneficial effects on NSCs self‐proliferation and mature neurons survival.
Yaliang Yu, Jianzhou Lv, Dan Ma, Ya Han, Yaheng Zhang, Shanlong Wang, Zhitao Wang   +6 more
wiley   +1 more source

The haematopoiesis transcription landscape [PDF]

Nature Cell Biology, 2012
openaire   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Appraising ascorbic acid as a chemoprevention agent for acute myeloid leukaemia using Mendelian Randomisation. [PDF]

Blood Cancer J
Beer SA, Went M, Hislop JM, Houlston R, Kaiser M.   +4 more
europepmc   +1 more source

Effectiveness of Autologous Hematopoietic Stem Cell Transplantation versus Alemtuzumab and Ocrelizumab in Relapsing Multiple Sclerosis: A Single Center Cohort Study

Annals of Neurology, EarlyView.
Objective To compare clinical and radiological outcomes among relapsing multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT), alemtuzumab (ATZ), and ocrelizumab (OCR). Methods From a London (UK) hospital‐based observational cohort, modeled data were obtained from 621 relapsing–remitting multiple sclerosis ...
Paolo Antonio Muraro, Antonio Zito, Alessio Signori, Maria Pia Sormani, Eleonora Rigoni, Federica Pollidoro, Roberto Bergamaschi, Alice Mariottini, Omar Malik, Ashwini Nandoskar, Victoria Singh‐Curry, Varun Mehra, Majid Kazmi, Ian Gabriel, Eli Silber, Richard Nicholas, Antonio Scalfari   +16 more
wiley   +1 more source

TET2 cascade: a novel regulator of chromatin structure and leukaemogenesis. [PDF]

Signal Transduct Target Ther
Dempke WCM, Fenchel K.
europepmc   +1 more source

Altered Expression of Hoxa1 Perturbs Haematopoiesis in a Dose-Dependent Manner and Induces Myelodysplasia in Mice

, 2016
Shuhying Tan, Alistair M. Chalk, Ana C Maluenda, Lenny Straszkowski, Jack O'Halloran, Meaghan Wall, Louise E. Purton   +6 more
openalex   +1 more source

Long-term tracking of haematopoietic clonal dynamics and mutations in non-human primate undergoing transplantation of lentivirally barcoded haematopoietic stem and progenitor cells. [PDF]

Br J Haematol
Hosuru RV, Yang J, Zhou Y, Gin A, Hayal TB, Hong SG, Dunbar CE, Wu C.   +7 more
europepmc   +1 more source

Extramedullary haematopoiesis

, 2016
Saikat Sarkar
openalex   +1 more source

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

The Anatomical Record, EarlyView.
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley   +1 more source