Results 51 to 60 of about 28,636 (337)

Resilient anatomy and local plasticity of naive and stress haematopoiesis

Nature
The bone marrow adjusts blood cell production to meet physiological demands in response to insults. The spatial organization of normal and stress responses are unknown owing to the lack of methods to visualize most steps of blood production.
Qingqing Wu, Jizhou Zhang, Sumit Kumar, Siyu Shen, Morgan Kincaid, Courtney B. Johnson, Yanan Sophia Zhang, Raphaël Turcotte, C. Alt, Kyoko Ito, Shelli Homan, Bryan E. Sherman, Tzu-Yu Shao, Anastasiya Slaughter, Benjamin Weinhaus, Baobao Song, Marie-Dominique Filippi, H. L. Grimes, Charles P. Lin, Keisuke Ito, S. Way, J. M. Kofron, Daniel Lucas   +22 more
semanticscholar   +1 more source

Parallel evolution of two distinct lymphoid proliferations in clonal haematopoiesis

Histopathology, 2022
Angioimmunoblastic T‐cell lymphoma (AITL) is genetically characterized by TET2 and DNMT3A mutations occurring in haematopoietic progenitor cells, and late events (e.g. the RHOA‐G17V mutation) associated with malignant transformation.
A. Attygalle, R. Dobson, Pui Kwan Chak, Katherine M Vroobel, D. Wren, H. Mugalaasi, Y. Morgan, Manmit Kaur, Raida Ahmad, Zi Chen, K. Naresh, M. Du   +11 more
semanticscholar   +1 more source

The role of the CCN family of proteins in blood cancers [PDF]

, 2016
Haematopoiesis is the term used to describe the production of blood cells. This is a tightly regulated hierarchical system in which mature circulating blood cells develop from a small population of haematopoietic stem (HSC) and progenitor cells within ...
Crawford, Lisa Judith, Irvine, Alexandra Elizabeth   +1 more
core   +1 more source

Systemic mastocytosis with associated myeloproliferative disease and precursor B lymphoblastic leukaemia with t(13;13)(q12;q22) involving FLT3. [PDF]

, 2008
Systemic mastocytoses represent neoplastic proliferations of mast cells. In about 20% of cases systemic mastocytoses are accompanied by clonal haematopoietic non-mast cell-lineage disorders, most commonly myeloid neoplasms.
Dirnhofer, S., Horny, H.-P., Jotterand, M., Muhlematter, D., Sotlar, Karl, Theocharides, A., Tzankov, A., Went, P.   +7 more
core   +1 more source

Single-cell lineage tracing unveils a role for Tcf15 in haematopoiesis

Nature, 2020
Bone marrow transplantation therapy relies on the life-long regenerative capacity of haematopoietic stem cells (HSCs)1,2. HSCs present a complex variety of regenerative behaviours at the clonal level, but the mechanisms underlying this diversity are ...
Alejo E. Rodriguez-Fraticelli, Caleb Weinreb, Shou-Wen Wang, R. P. Migueles, Maja Jankovic, Marc Usart, Allon M. Klein, S. Lowell, F. Camargo   +8 more
semanticscholar   +1 more source

Tribbles in normal and malignant haematopoiesis [PDF]

Biochemical Society Transactions, 2015
The tribbles protein family, an evolutionarily conserved group of pseudokinases, have been shown to regulate multiple cellular events including those involved in normal and malignant haematopoiesis. The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ...
Kelly S. Rome, Sarah J. Stein, Ethan A. Mack, Warren S. Pear   +3 more
openaire   +3 more sources

Extramedullary haematopoiesis in the adrenal glands [PDF]

BMJ Case Reports, 2020
Extramedullary haematopoiesis (EMH) is the formation of cellular components of blood, occurring outside of the bone marrow. This is a result of cytokine induction for increased cell production and a greater availability of pluripotent stem cells. While EMH is physiological during fetal development,
Mathews Edatharayil Kurian, Felix K Jebasingh, Elanthenral Sigamani, Nihal Thomas   +3 more
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Development of flow focusing device for the visualization of leukocyte rolling adhesion [PDF]

, 2018
La microfluídica es un área de la microtecnología basada en chips de PDMS que está siendo utilizada cada vez más en multitud de aplicaciones. Una de estas aplicaciones es la investigación biomédica.
Morales Navarrete, Pablo
core  

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]

, 2011
The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff, Abtahian, Alice Y. Pollitt, Aparicio-Vergara, Bertozzi, Bohmer, Brenda A. Finney, Caetano Reis e Sousa, Carramolino, Caton, Cecile Bénézech, Chagraoui, Cheng, Christou, Clausen, Colonna, Craig E. Hughes, Cueni, de Boer, Diego Mourao-Sa, Edina Schweighoffer, Francesca Barone, Gerard B. Nash, Gustafsson, Hodivala-Dilke, Hughes, Hughes, Humphreys, Ichise, Kate L. Lowe, Kaufmann, Kerrigan, Leyre Navarro-Núñez, Makinen, Martin-Villar, May, Mocsai, Mourao-Sa, Navarro, Navarro, Nicholas Smithers, Nieswandt, Pardridge, Ramirez, Saijo, Schacht, Sebzda, Spalton, Stacey A. Langan, Steve P. Watson, Steve Sheardown, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Tammela, Tang, Tiedt, Tober, Turner, Uhrin, Victor L. J. Tybulewicz, Warburton, Watson, Williams, Xie, Xu   +66 more
core   +2 more sources