Extramedullary haematopoiesis in the adrenal glands [PDF]
BMJ Case Reports, 2020 Extramedullary haematopoiesis (EMH) is the formation of cellular components of blood, occurring outside of the bone marrow. This is a result of cytokine induction for increased cell production and a greater availability of pluripotent stem cells. While EMH is physiological during fetal development,
Mathews Edatharayil Kurian +3 more
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The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]
, 2012 Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
A Quintas-Cardama +39 more
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Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis. [PDF]
, 2022 Peptidylarginine deiminases (PADIs) are strongly associated with the development of autoimmunity, neurodegeneration and cancer but their physiological roles are ill-defined.
Christophorou, MA +6 more
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Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma
Cells, 2019 Haematopoiesis is a tightly orchestrated process where a pool of hematopoietic stem and progenitor cells (HSPCs) with high self-renewal potential can give rise to both lymphoid and myeloid lineages.
Mojgan Djavaheri-Mergny +3 more
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Graph-Based Integration of Histone Modification Profiles
Mathematics, 2022 In this work, we introduce a similarity-network-based approach to explore the role of interacting single-cell histone modification signals in haematopoiesis—the process of differentiation of blood cells.
Federica Baccini +2 more
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The discovery of lymphatic system as a turning point in medical knowledge: Aselli, Pecquet and the end of hepatocentrism [PDF]
, 2017 In this paper, I would like to analyse the impact of the discovery of lymphatic system on the development of the modern conception of human body. The discovery of lymphatics, as that of blood circulation, has in fact questioned important tenets of Galen ...
Tonetti, Luca
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In Vitro Human Haematopoietic Stem Cell Expansion and Differentiation
Cells, 2023 The haematopoietic system plays an essential role in our health and survival. It is comprised of a range of mature blood and immune cell types, including oxygen-carrying erythrocytes, platelet-producing megakaryocytes and infection-fighting myeloid and ...
Yavor K. Bozhilov +3 more
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Tribbles in normal and malignant haematopoiesis [PDF]
Biochemical Society Transactions, 2015 The tribbles protein family, an evolutionarily conserved group of pseudokinases, have been shown to regulate multiple cellular events including those involved in normal and malignant haematopoiesis. The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ...
Kelly S. Rome +3 more
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Frontiers in Immunology, 2023 The Haematopoietically expressed homeobox transcription factor (Hhex) is a transcriptional repressor that is of fundamental importance across species, as evident by its evolutionary conservation spanning fish, amphibians, birds, mice and humans.
Jacob T. Jackson +4 more
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Bone marrow haematopoiesis in patients with COVID-19 [PDF]
, 2023 AIMS Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection broadly affects organ homeostasis, including the haematopoietic system. Autopsy studies are a crucial tool for investigation of organ-specific pathologies.
Frank, Angela +11 more
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