Results 31 to 40 of about 24,687 (303)

Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches

Molecules, 2018
Acute myeloid leukemia (AML), the most common acute leukemia in the adult, is believed to arise as a consequence of multiple molecular events that confer on primitive hematopoietic progenitors unlimited self-renewal potential and cause defective ...
Maria Mesuraca, Nicola Amodio, Emanuela Chiarella, Stefania Scicchitano, Annamaria Aloisio, Bruna Codispoti, Valeria Lucchino, Ylenia Montalcini, Heather M. Bond, Giovanni Morrone   +9 more
doaj   +1 more source

Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome

EBioMedicine, 2020
Background: Chronic myelomonocytic leukaemia (CMML) is a clinically heterogeneous stem cell malignancy with overlapping features of myelodysplasia and myeloproliferation. Over 90% of patients carry mutations in epigenetic and/or splicing genes, typically
Daniel H Wiseman, Syed M Baker, Arundhati V Dongre, Kristian Gurashi, Joanna A Storer, Tim CP Somervaille, Kiran Batta   +6 more
doaj   +1 more source

Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia

Frontiers in Immunology, 2021
In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained in micro-anatomical structures by adhesion molecules that regulate HSC quiescence, proliferation and commitment.
Julien M. P. Grenier, Céline Testut, Cyril Fauriat, Stéphane J. C. Mancini, Michel Aurrand-Lions   +4 more
doaj   +1 more source

Oral feeding with Arachidonic Acid (AA) and Docosahexanoic Acid (DHA) help in better recovery of haematopoiesis in sub-lethally irradiated mice

Biomedical Research Journal, 2016
Haematopoiesis is severely hampered after exposure to ionizing radiations. Role of polyunsaturated fatty acids (PUFAs) during embryonic development as well as during various physiological processes is well established.
Kedar Limbkar, Vaijayanti Kale, Lalita Limaye   +2 more
doaj   +1 more source

Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

eLife, 2022
Background: Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for chronic diseases.
Amy L Roberts, Alessandro Morea, Ariella Amar, Antonino Zito, Julia S El-Sayed Moustafa, Max Tomlinson, Ruth CE Bowyer, Xinyuan Zhang, Colette Christiansen, Ricardo Costeira, Claire J Steves, Massimo Mangino, Jordana T Bell, Chloe CY Wong, Timothy J Vyse, Kerrin S Small   +15 more
doaj   +1 more source

Regulation of NF-κB by PML and PML-RARα [PDF]

, 2017
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar, Carmody, Ruaidhri J., Chen, Youhai H., Keeshan, Karen, Lindsay, Andrew J., McCaffrey, Mary W., Mitxitorena, Izaskun, Pandolfi, Pier Paolo, Wan, Xiaochun   +8 more
core   +1 more source

Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function

Frontiers in Physiology, 2022
The haematopoietic system is a classical stem cell hierarchy that maintains all the blood cells in the body. Haematopoietic stem cells (HSCs) are rare, highly potent cells that reside at the apex of this hierarchy and are historically some of the most ...
Beatrice Rix, Andres Hernandez Maduro, Katherine S. Bridge, William Grey   +3 more
doaj   +1 more source

SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development [PDF]

Open Biology, 2016
During embryogenesis, the three SOXF transcription factors, SOX7, SOX17 and SOX18, regulate the specification of the cardiovascular system and are also involved in the development of haematopoiesis.
Sara Cuvertino, Georges Lacaud, Valerie Kouskoff   +2 more
doaj   +1 more source

Efectele suplimentării hranei găinilor tinere cu produsul zoobior asupra statusului clinico-hematologic

Agricultural Science, 2021
The study aimed to investigate how the local product ZooBioR, obtained by modern technologies from Spirulina platensis, influences the health and, in particular, the parameters-markers of the clinical and haema-tological status in hens, in the first ...
Gheorghe PISTOL, Vasile MACARI, Victor PUTIN, Ana ROTARU   +3 more
doaj   +1 more source

An interesting diagnosis for a presacral mass: case report [PDF]

, 2009
A presacral mass can present a diagnostic dilemma for the surgical oncologist. Differential diagnoses include congenital causes such as teratoma or chordoma, neurological causes such as neurilemoma or neurofibroma or other malignancies such as lymphoma ...
John L Slavin, Matthew L Broadhead, Peter FM Choong, Sina Babazadeh   +3 more
core   +1 more source