STAR Protocols, 2021 Summary: Little is known about the emergence of blood progenitors during human embryogenesis due to ethical reasons and restricted embryo access. The use of human embryonic stem cells (hESCs) as a model system offers unique opportunities to dissect human
Eva Garcia-Alegria +3 more
doaj +1 more source
Preliminary investigation of the effects of long-term dietary intake of genistein and daidzein on hepatic histopathology and biochemistry in domestic cats (Felis catus) [PDF]
, 2012 Dietary isoflavones have been hypothesised to play a role in hepatic veno-occlusive disease in captive exotic felids, although empirical evidence is lacking. This study aimed to investigate the effect of long-term (>1 year) dietary genistein and daidzein
Cave, NJ +4 more
core +1 more source
Consequences of HIV infection in the bone marrow niche
Frontiers in Immunology, 2023 Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients.
Candice Lee Herd +4 more
doaj +1 more source
South African Medical Journal, 2019 Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and neutropenia). Although there is a definite association between the severity of cytopenia and HIV disease stage, this relationship is not
Durandt, Chrisna +7 more
openaire +4 more sources
TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity
eLife, 2023 Monocytes are heterogeneous innate effector leukocytes generated in the bone marrow and released into circulation in a CCR2-dependent manner. During infection or inflammation, myelopoiesis is modulated to rapidly meet the demand for more effector cells ...
William D Jackson +9 more
doaj +1 more source
Fat for fuel: lipid metabolism in haematopoiesis
Clinical & Translational Immunology, 2019 The importance of metabolic regulation in the immune system has launched back into the limelight in recent years. Various metabolic pathways have been examined in the context of their contribution to maintaining immune cell homeostasis and function ...
Gerard Pernes +3 more
doaj +1 more source
The discovery of lymphatic system as a turning point in medical knowledge: Aselli, Pecquet and the end of hepatocentrism [PDF]
, 2017 In this paper, I would like to analyse the impact of the discovery of lymphatic system on the development of the modern conception of human body. The discovery of lymphatics, as that of blood circulation, has in fact questioned important tenets of Galen ...
Tonetti, Luca
core +2 more sources
Germline risk of clonal haematopoiesis [PDF]
Nature Reviews Genetics, 2021 Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with somatic mutations that is associated with an increased risk of haematological malignancies, cardiovascular disease and all-cause mortality. CH may be caused by point mutations in genes associated with myeloid neoplasms, chromosomal copy number changes and loss of ...
Alexander J. Silver +2 more
openaire +2 more sources
ZNF423: A New Player in Estrogen Receptor-Positive Breast Cancer
Frontiers in Endocrinology, 2018 Preventive therapy can target hormone-responsive breast cancer (BC) by treatment with selective estrogen receptor modulators (SERMs) and reduce the incidence of BC.
Heather M. Bond +8 more
doaj +1 more source
The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]
, 2012 Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
A Quintas-Cardama +39 more
core +2 more sources