Results 1 to 10 of about 138,351 (120)
Cancer Cell International, 2023 Background Development of precision medicine requires the identification of easily detectable and druggable biomarkers. Despite recent targeted drug approvals, prognosis of acute myeloid leukemia (AML) patients needs to be greatly improved, as relapse ...
Laia Cuesta-Casanovas +7 more
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PTEN/PI3K/Akt pathway alters sensitivity of T-cell acute lymphoblastic leukemia to l-asparaginase
Scientific Reports, 2022 Childhood T-cell acute lymphoblastic leukemia (T-ALL) still remains a therapeutic challenge due to relapses which are resistant to further treatment. l-asparaginase (ASNase) is a key therapy component in pediatric T-ALL and lower sensitivity of leukemia ...
Katerina Hlozkova +10 more
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Epigenetics, 2023 DNA methylation, one of the best characterized epigenetic marks in the human genome, plays a pivotal role in gene transcription regulation and other biological processes in humans.
Aleix Noguera-Castells +3 more
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Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution
Nature Communications, 2023 Here the authors present the low input capture Hi-C (liCHi-C) method, a cost-effective, flexible method to map and robustly compare promoter interactomes at high resolution.
Laureano Tomás-Daza +15 more
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Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome
Epigenetics, 2022 Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments.
Carlos A. Garcia-Prieto +6 more
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HemaSphere, 2022 Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic disorders characterized by dysplasia, ineffective hematopoiesis, and predisposition to secondary acute myeloid leukemias (sAML).
Marguerite-Marie Le Pannérer +9 more
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Scientific Reports, 2021 Haematopoietic malignancies are frequently characterized by karyotypic abnormalities. The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations.
Michael Maher +12 more
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Disruption of the RNA modifications that target the ribosome translation machinery in human cancer
Molecular Cancer, 2020 Genetic and epigenetic changes deregulate RNA and protein expression in cancer cells. In this regard, tumors exhibit an abnormal proteome in comparison to the corresponding normal tissues.
Maxime Janin +2 more
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New Therapeutic Approaches for Acute Myeloid Leukaemia
European Medical Journal, 2021 Acute myeloid leukaemia (AML) is a genetically heterogeneous haematopoietic neoplasm characterised by the accumulation of transformed immature blood progenitors in bone marrow.
Ruth M Risueno +3 more
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Epigenetics, 2020 One caveat in cancer research is the dependence of certain experimental systems that might not really reflect the properties of the primary tumours. The recent irruption of 3D cultured cells termed organoids could render a better representation of the ...
Ricky Joshi +5 more
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