Results 31 to 40 of about 253,634 (313)
Cell Death Discovery, 2022 Dysregulation of the BCL-2 family is implicated in protecting chronic myeloid leukemia (CML) cells from intracellular damage and BCR::ABL1-inhibition with tyrosine kinase inhibitors (TKIs) and may be a viable therapeutic target in blast phase (BP-)CML ...
Narissa Parry +7 more
doaj +1 more source
Hydroxychloroquine for chronic myeloid leukemia: complete cure on the horizon? [PDF]
, 2011 No abstract ...
Amaravadi +20 more
core +1 more source
British Journal of Haematology, 2015 SummaryThe IKZF1 gene at 7p12.2 codes for IKAROS (also termed IKZF1), an essential transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its importance is underlined by the fact that deregulation of IKAROS results in leukaemia in both mice and men.
Linda, Olsson, Bertil, Johansson
openaire +2 more sources
Another treatment option for relapsed or refractory chronic lymphocytic leukaemia. [PDF]
, 2017 We hereby report the clinical and biologic features of 33 of 4680 (0.7%) patients with chronic lymphocytic leukemia (CLL), managed at 10 Italian centers, who developed Hodgkin lymphoma (HL), a rare variant of Richter syndrome.
Mauro, Francesca Romana
core +1 more source
Lymphohaematopoietic malignancies in Scottish military veterans: Retrospective cohort study of 57,000 veterans and 173,000 non-veterans [PDF]
, 2017 Background: Lymphohaematopoietic malignancies are common in the general population. There have been concerns that military service may be associated with increased risk as a result of occupational exposures.
Bergman, Beverly P. +2 more
core +1 more source
Molecular Oncology, 2022 Transcribed ultraconserved regions (T‐UCRs) are noncoding RNAs derived from DNA sequences that are entirely conserved across species. Their expression is altered in many tumor types, and, although a role for T‐UCRs as regulators of gene expression has ...
Marta Soler +8 more
doaj +1 more source
Chemical approaches to targeting drug resistance cancer stem cells [PDF]
, 2016 STEMCHEM is a COST action aiming to target causes of drug resistance in cancer stem cells. Cancer stem cells are cells which are believed to be responsible for the larger part of the regenerative capacity of cancers.
Blaire Theuma, Krystle +6 more
core +1 more source
The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors [PDF]
, 2014 Chronic myeloid leukemia (CML) is initiated and maintained by the tyrosine kinase BCR-ABL which activates a number of signal transduction pathways, including PI3K/AKT signaling and consequently inactivates FOXO transcription factors.
Bhatia +38 more
core +2 more sources
Insights from the genetic and transcriptional characterization of a cancer of unknown primary (CUP)
EMBO Molecular Medicine, 2020 Cancer of unknown primary (CUP) defines a heterogeneous group of metastatic tumors that lack an identifiable primary tumor, despite a standardized diagnostic work‐up (Fizazi et al, 2015).
Veronica Davalos, Manel Esteller
doaj +1 more source
Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia
Molecular Oncology, 2021 Acute myeloid leukaemia (AML) is a clinically and molecularly heterogeneous disease characterised by uncontrolled proliferation, block in differentiation and acquired self‐renewal of hematopoietic stem and myeloid progenitor cells.
Myint Myat Khine Aung +3 more
doaj +1 more source