Results 31 to 40 of about 184,092 (245)

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Time to haematologist visit and non-haematological referral from primary health care during blood cancer diagnosis – findings from a large national survey in Australia

BMC Cancer
Background Blood cancers are the third most common cancer in Australia. However, little is known about their diagnostic pathway in the Australian context.
Mohammad Radwanur Talukder, Emily Kovacev, Bill Stavreski, Sarah DeLacey   +3 more
doaj   +1 more source

Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients

Acta Dermato-Venereologica, 2022
Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time.
Hwa Jung Yook, Joon Ho Son, Yeong Ho Kim, Ju Hee Han, Ji Hyun Lee, Young Min Park, Nack-Gyun Chung, Hee Je Kim, Chul Hwan Bang   +8 more
doaj   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

Clonality in adult T-cell leukaemia/lymphoma [PDF]

, 2014
Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that persists lifelong within the infected host by driving expansion of infected CD4+T-cells. It is the cause of adult T-cell leukaemia/lymphoma (ATL), an aggressive CD4+ T-cell malignancy, which
Cook, Lucy
core   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

The stem region of group A transferase is crucial for its specificity, and its alteration promotes heterologous Forssman synthase activity

Scientific Reports, 2023
Some stem region mutants of human blood group A transferase (hAT) possess Forssman synthase (FS) activity, but very little is known about the mechanisms responsible for this enzymatic crosstalk.
Emili Cid, Miyako Yamamoto, Laura Barrero, Fumiichiro Yamamoto   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The DNA methylation landscape of hematological malignancies: an update

Molecular Oncology, 2020
The rapid advances in high‐throughput sequencing technologies have made it more evident that epigenetic modifications orchestrate a plethora of complex biological processes.
Pedro Blecua, Laura Martinez‐Verbo, Manel Esteller   +2 more
doaj   +1 more source

Histone Variants and Their Chaperones in Hematological Malignancies

HemaSphere, 2023
Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins.
Ecem Kirkiz, Oliver Meers, Florian Grebien, Marcus Buschbeck   +3 more
doaj   +1 more source