Results 21 to 30 of about 253,634 (313)

MUC1-C drives myeloid leukaemogenesis and resistance to treatment by a survivin-mediated mechanism [PDF]

, 2018
Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with an unmet need for improved therapies. Responses to standard cytotoxic therapy in AML are often transient because of the emergence of chemotherapy-resistant disease.
Anastasiadou, Eleni, Avigan, David, Bar-Natan, Michal, Cole, Leandra, Coll, Maxwell D., Ephraim, Adam, Jain, Salvia, Kharbanda, Akriti, Kufe, Donald, Kufe, Turner, Leaf, Rebecca K., Nahas, Myrna, Orr, Shira, Palmer, Kristen, Pyzer, Athalia, Rahimian, Maryam, Rajabi, Hasan, Rosenblatt, Jacalyn, Stroopinsky, Dina, Tagde, Ashujit, Washington, Abigail   +20 more
core   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Neonatal leukaemia [PDF]

British Journal of Haematology, 2018
SummaryNeonatal leukaemia is defined as occurring within the first 28 days of life and most, if not all, cases are congenital. With the exception of Down syndrome‐associated transient abnormal myelopoiesis, which is not considered here, neonatal leukaemias are rare.
Irene Roberts, Nicholas J. Fordham, Anupama Rao, Barbara J. Bain   +3 more
openaire   +3 more sources

The application of BH3 mimetics in myeloid leukemias

Cell Death and Disease, 2021
Execution of the intrinsic apoptotic pathway is controlled by the BCL-2 proteins at the level of the mitochondrial outer membrane (MOM). This family of proteins consists of prosurvival (e.g., BCL-2, MCL-1) and proapoptotic (e.g., BIM, BAD, HRK) members ...
Narissa Parry, Helen Wheadon, Mhairi Copland   +2 more
doaj   +1 more source

Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias [PDF]

, 2009
This article is available open access through the publisher’s website at the link below. Copyright @ 2009 Macmillan Publishers Ltd.No abstract available (Letter to the editor).The Leukaemia Research ...
Ballabio, E, Cantarella, CD, Di Mare, P, Federico, C, Hall, G, Harbott, J, Hughes, J, Saccone, S, Tosi, S   +8 more
core   +1 more source

Low HOX gene expression in PML-RARα-positive leukemia results from suppressed histone demethylation

Epigenetics, 2018
Homeobox (HOX) genes are frequently dysregulated in leukemia. Previous studies have shown that aberrant HOX gene expression accompanies leukemogenesis and affects disease progression and leukemia patient survival.
Katerina Rejlova, Alena Musilova, Karolina Skvarova Kramarzova, Marketa Zaliova, Karel Fiser, Meritxell Alberich-Jorda, Jan Trka, Julia Starkova   +7 more
doaj   +1 more source

Constitutive cytoplasmic localization of p21Waf1/Cip1 affects the apoptotic process in monocytic leukaemia [PDF]

, 2003
In the present study, we analysed the expression and localization of p21Waf1/Cip1 in normal and malignant haematopoietic cells. We demonstrate that in normal monocytic cells, protein kinase C (PKC)-induced p21 gene activation, which is nuclear factor-κB (
A de Thonel, A Rambaldi, A Suzuki, A Suzuki, A Suzuki, A Suzuki, AS Baldwin Jr, CD Bloomfield, D Toullec, E Kobayashi, E Schreiber, H Ichijo, HY Chang, J Chen, J Chen, J Lin, JE Thompson, JJ Schuringa, JM Bennett, JM Herbert, JM Lai, K Kuno, K Kuno, KN Pennington, KU Birkenkamp, KU Birkenkamp, KU Birkenkamp, L Koenderman, L Rossig, LM Tuyt, M Asada, M Asada, M Mizuki, M Nakanishi, ML Guzman, MT Scott, MV Blagosklonny, MW Mayo, PJ Fialkow, RA Steinman, TS Finco, Y Arvidsson, Y Li, Y Luo, Y Miyazaki   +44 more
core   +3 more sources

Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12 [PDF]

, 2012
Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling ...
A Hochhaus, A Ptasznik, A Serrels, A Veldurthy, AC Shor, Alison M. McCaig, Alison M. Michie, AM McCaig, CD Allen, CM Pleiman, DY Hallaert, Emilio Cosimo, J Hoellenriegel, J Hoellenriegel, JA Burger, JA Burger, JA Burger, JW Friedberg, LJ Lombardo, M Buchner, M Burger, M Lopez-Guerra, M Niedermeier, M O'Hayre, MF de Rooij, Michael T. Leach, MP Quiroga, O Hantschel, P Ghia, PC Amrein, R Buettner, RE Hayden, S Braselmann, S Ponader, S Willimott, SJ Richardson, Spencer B. Gibson, Y Nakata, Z Song   +38 more
core   +6 more sources

Self\u2010esteem and academic difficulties in preadolescents and adolescents healed from paediatric leukaemia [PDF]

, 2017
Adolescents with cancer may demonstrate problems in their self\u2010esteem and schooling. This study aims to screen the preadolescents and adolescents more at risk in their self\u2010esteem perception and schooling difficulties post\u2010five years from ...
Basso, Giuseppe, Bonichini, Sabrina, Pillon, Marta, Taverna, Livia, Tremolada, Marta   +4 more
core   +1 more source

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
A Quintas-Cardama, A Quintas-Cardama, A Quintas-Cardama, AJ Tipping, AJ Tipping, B Zhang, C Akgul, C Bellodi, G Gurel, H de Lavallade, H Konig, HG Jorgensen, HM Kantarjian, J Kuroda, KJ Aichberger, L Legros, M Copland, M Copland, NB Heaney, R Chen, R Tang, RG Powell, RM Stone, S Chu, SM Graham, SV Sharma, T Kobayashi, Y Chen   +27 more
core   +1 more source