Results 11 to 20 of about 253,634 (313)
Scientific Reports, 2021 Haematopoietic malignancies are frequently characterized by karyotypic abnormalities. The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations.
Michael Maher +12 more
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Disruption of the RNA modifications that target the ribosome translation machinery in human cancer
Molecular Cancer, 2020 Genetic and epigenetic changes deregulate RNA and protein expression in cancer cells. In this regard, tumors exhibit an abnormal proteome in comparison to the corresponding normal tissues.
Maxime Janin +2 more
doaj +1 more source
Race/ethnicity and the risk of childhood leukaemia: a case-control study in California. [PDF]
, 2015 BackgroundWe conducted a large registry-based study in California to investigate the association between race/ethnicity and childhood leukaemia focusing on two subtypes: acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML).MethodsWe ...
Cockburn, Myles +5 more
core +2 more sources
New Therapeutic Approaches for Acute Myeloid Leukaemia
European Medical Journal, 2021 Acute myeloid leukaemia (AML) is a genetically heterogeneous haematopoietic neoplasm characterised by the accumulation of transformed immature blood progenitors in bone marrow.
Ruth M Risueno +3 more
doaj +1 more source
Quality of life of caregivers and impact on the nuclear family of children with leukaemia in the National Cancer Institute of Sri Lanka [PDF]
, 2015 Childhood leukaemia is the commonest cancer in children aged below 15 years. A diagnosis of childhood leukaemia is a devastating experience for any parent. This hospital-based descriptive cross sectional study aimed to assess the quality of life (QOL) of
Goonawardena, C S E +2 more
core +1 more source
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]
, 2016 Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe +20 more
core +2 more sources
Infant leukaemias - Congenital leukaemias - Neonatal leukaemias [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on Infant leukaemias - Congenital leukaemias - Neonatal leukaemias, with data on clinics, and the genes involved.
openaire +1 more source
Epigenetics, 2020 One caveat in cancer research is the dependence of certain experimental systems that might not really reflect the properties of the primary tumours. The recent irruption of 3D cultured cells termed organoids could render a better representation of the ...
Ricky Joshi +5 more
doaj +1 more source
Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase
BMC Cancer, 2020 Background Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients.
Katerina Hlozkova +12 more
doaj +1 more source
Nature Communications, 2021 Azacitidine (AZA) treatment is used for patients with myelodysplasias that cannot undergo bone marrow transplantation; however, AZA treatment is only partially effective.
Jeannine Diesch +17 more
doaj +1 more source