Results 51 to 60 of about 24,687 (303)

Effect of simvastatin on thrombopoiesis in porcine bone marrow

Journal of Veterinary Research, 2019
Introduction: Statins are pharmacological agents commonly used to lower serum cholesterol level. The aim of the experiment was to investigate the effect of the statin simvastatin on thrombopoiesis in the porcine model because it is the closest to the ...
Snarska Anna, Wysocka Dominika, Rytel Liliana   +2 more
doaj   +1 more source

Hemophagocytic Lymphohistiocytosis Triggered by Legionella pneumophila and SARS‐CoV‐2 Infection in GATA2 Deficiency

Clinical Case Reports
Germline GATA2 deficiency predisposes to bone marrow failure, myeloid neoplasia, and immune dysregulation. The syndrome is often complicated by infection with intracellular pathogens and viruses, autoimmunity, and inflammation.
Harry Wilson, Nuno Borges, Matthew Collin, Callum Wright   +3 more
doaj   +1 more source

In Vitro Human Haematopoietic Stem Cell Expansion and Differentiation

Cells, 2023
The haematopoietic system plays an essential role in our health and survival. It is comprised of a range of mature blood and immune cell types, including oxygen-carrying erythrocytes, platelet-producing megakaryocytes and infection-fighting myeloid and ...
Yavor K. Bozhilov, Ian Hsu, Elizabeth J. Brown, Adam C. Wilkinson   +3 more
doaj   +1 more source

The role of the CCN family of proteins in blood cancers [PDF]

, 2016
Haematopoiesis is the term used to describe the production of blood cells. This is a tightly regulated hierarchical system in which mature circulating blood cells develop from a small population of haematopoietic stem (HSC) and progenitor cells within ...
Crawford, Lisa Judith, Irvine, Alexandra Elizabeth   +1 more
core   +1 more source

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan

iScience
Summary: Rapid hematopoietic adaptations are important for building and sustaining the biological response to β-glucan. The signals involved in these early events have not yet been fully explored. Given that type I interferons are produced in response to
Yangsong Xu, Man K.S. Lee, Nicole A. de Weerd, Ziyue Fu, Camilla Bertuzzo Veiga, Dragana Dragoljevic, Dmitri Sviridov, Paul J. Hertzog, Andrew J. Fleetwood, Andrew J. Murphy   +9 more
doaj   +1 more source

Graph-Based Integration of Histone Modification Profiles

Mathematics, 2022
In this work, we introduce a similarity-network-based approach to explore the role of interacting single-cell histone modification signals in haematopoiesis—the process of differentiation of blood cells.
Federica Baccini, Monica Bianchini, Filippo Geraci   +2 more
doaj   +1 more source

Molecular mechanisms in haematological malignancies [PDF]

, 2009
Haematopoiesis requires the constant production of large numbers of peripheral blood cells. This process is under tight control of transcription factor networks as well as cytokines, growth factors and hormones.
Avellino, Roberto, Grech, Godfrey, Schembri-Wismayer, Pierre   +2 more
core  

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia [PDF]

, 2017
Additional sex combs-like (ASXL) proteins are mammalian homologues of additional sex combs (Asx), a regulator of trithorax and polycomb function in Drosophila.
A Balasubramani, A Dey, A Klinakis, A Maiques-Diaz, A Ortega-Molina, A Ptasinska, A Ptasinska, A Rada-Iglesias, A Tonks, AV Krivtsov, AV Krivtsov, B Langmead, C Bach, CL Fisher, CL Fisher, DA Sinclair, DH Spencer, F Thol, G Genovese, H O'Geen, H Oguro, H Xie, HA Baskind, I Hidalgo, J Wang, J Zhang, JB Micol, JC Byrd, JD Buenrostro, JH Martens, JP Patel, K Klauke, K Rege, KD Rasmussen, LM LaFave, M Higuchi, M Katoh, M Mochizuki-Kashio, M Pratcorona, M Yan, MA Hatlen, MP Creyghton, N Duployez, ND Heintzman, O Abdel-Wahab, O Abdel-Wahab, P Ernst, R Bejar, R Huether, R Itzykson, S Heinz, S Jaiswal, S Lin, SC Lee, T Haferlach, T McKerrell, T Miyamoto, T Miyamoto, T Shima, TA Milne, U Thorsteinsdottir, U Thorsteinsdottir, UH Park, UH Park, V Gelsi-Boyer, Y Li, Y Zhang, ZJ Faber   +67 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source