Results 71 to 80 of about 22,415 (245)

Idiopathic arterial calcification of infancy : a case report [PDF]

, 2004
Idiopathic arterial calcification of infancy is a rare condition characterized by extensive calcification and stenosis of large and medium sized arteries.
Kuruvilla, Sarah, Sundaram, Sandhya, Thirupuram, S.   +2 more
core  

Molecular landscapes of human hematopoietic stem cells in health and leukemia. [PDF]

, 2015
Blood cells are organized as a hierarchy with hematopoietic stem cells (HSCs) at the root. The advent of genomic technologies has opened the way for global characterization of the molecular landscape of HSCs and their progeny, both in mouse and human ...
Dick, John E, Dunant, Cyrille F, Laurenti, Elisa, Santoro, Antonella, Vedi, Aditi   +4 more
core   +1 more source

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J. Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L. Mangal, Abhirami P. Suresh, Niveda M. Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D. Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E. Stabenfeldt, Abhinav P. Acharya   +28 more
wiley   +1 more source

Protein Tyrosine Phosphatase 1B (PTP1B) in the immune system [PDF]

, 2015
Journal not available online when checked 02/04/19.
Delibegovic, Mirela, Le Sommer, Samantha, Martin-Granados, Christina, Martina, Pesaresi   +3 more
core  

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Distinctive functions of methionine aminopeptidase II in embryonic haematopoiesis in zebrafish embryos [PDF]

, 2010
Oral presentationINTRODUCTION: Methionine aminopeptidase 2 (MetAP-2) is known to be the target of an anti-angiogenesis compound fumagillin and has been investigated for its robust expression in human cancers and its antiproliferative effects on ...
Chung, MIS, Leung, AYH, Liang, RHS, Lin, RHC, Ma, ACH, Yang, D   +5 more
core  

Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I [PDF]

, 2017
Umbilical cord blood (UCB) is a promising source of stem cells to use in early haematopoietic stem cell transplantation (HSCT) approaches for several genetic diseases that can be diagnosed at birth.
A Oikawa, A Pievani, A Pievani, A Scaradavou, AE Willing, B Sacchetti, C Davenport, C Schulte, CM Simonaro, DC Mendez, DE Harrison, DE Harrison, DJ Rowan, DK Kim, DL Selle, DT Harris, F Gatto, F Kubaski, F Migishima, FL Wilkinson, HE Broxmeyer, J Palis, JJ Boelens, K Ohmi, K Uchida, K Uchida, KK Ballen, L Lu, LA Clarke, LA Clarke, M Aldenhoven, M Aldenhoven, M Aldenhoven, M Aldenhoven, M Beck, M Schmidt, ME Bernardo, MF Garcia-Rivera, O Levy, S Coşkun, S Garbuzova-Davis, S Jayaraman, S Tomatsu, S Tomatsu, S Tomatsu, SC Kuehn, SH Boyer, SJ Morrison, SL Staba, VK Prasad, VK Prasad, W Chuan, XY Zhong, Y Zheng, ZY Li   +54 more
core   +2 more sources

Progress and Application of Multifunctional Hydrogel in Radioactive Skin Injury

Advanced Materials Interfaces, EarlyView.
This review examines healing challenges in radiation‐wound injuries, where ionizing radiation impairs immune and tissue repair processes. Hydrogels, with their biocompatibility, antimicrobial properties, and drug delivery capabilities, present a transformative solution. It compares hydrogel efficacy in radiation‐induced versus common wounds, highlights
Xinyue Cui, Jingyi Wang, Xinyi Xu, Xiqian Cao, Yingtang Zhou, Jiaming Guo   +5 more
wiley   +1 more source

GFI1 proteins regulate stem cell formation in the AGM [PDF]

, 2015
In vertebrates, the first haematopoietic stem cells (HSCs) with multi-lineage and long-term repopulating potential arise in the AGM (aorta-gonad-mesonephros) region.
A Bigas, AC Zovein, AJ Medvinsky, AM Müller, Berthold Göttgens, BK Hadland, C Lancrin, C Lancrin, C Lancrin, Catherine Robin, CF Pereira, Christophe Lancrin, Crispin Miller, CT Foster, Elli Marinopoulou, EYN Lam, G Costa, G Costa, G Lacaud, G Swiers, Georges Lacaud, HJ Fehling, HM Eilken, J Guiu, J Nichols, J Palis, J Wang, J-C Boisset, J-C Boisset, JM Frame, JY Bertrand, K Batta, K Fiolka, K Kissa, K Kumano, KE McGrath, L Vassen, L Wang, L Wang, M Kyba, M Lichtinger, M Lie-A-Ling, M Stefanska, MFTR de Bruijn, MFTR de Bruijn, MH Ledran, Milena Mazan, MJ Chen, MJ Chen, MJ Vogel, Monika Stefanska, NK Wilson, P Kumaravelu, P Sroczynska, P Sroczynska, Q Wang, R Yücel, Rahima Patel, RL Clarke, Roshana Thambyrajah, S Nishikawa, S Pearson, S Rybtsov, S Saleque, S Taoudi, S Taoudi, Shaun Cowley, T Jaffredo, T Möröy, T North, T Okuda, T Yokomizo, Tarik Möröy, TE North, TE North, Thomas Clapes, V Moignard, Valerie Kouskoff, Victoria Moignard, VM Sandler, W Kim, WA Whyte, WJ Harris, Yaoyong Li   +83 more
core   +2 more sources

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source