Results 11 to 20 of about 18,669 (233)

Perioperative management of a patient with haemophilia B and PSVT undergoing radiofrequency ablation: A case report [PDF]

Journal of International Medical Research, 2023
Haemophilia B is a rare inherited bleeding disorder in which patients have impaired coagulation. This study describes a patient with Haemophilia B and paroxysmal supraventricular tachycardia (PSVT) who underwent radio frequency catheter ablation (RFCA ...
Yu Gan, Liping Ma, Pihua Fang
doaj   +2 more sources

Eftrenonacog Alfa: A Review in Haemophilia B [PDF]

Drugs, 2023
Eftrenonacog alfa (Alprolix®) is an extended half-life recombinant factor IX (rFIX)-Fc fusion protein (hereafter referred to as rFIXFc). Administered as an intravenous bolus, it is approved for prophylactic use and the treatment of bleeding in patients with haemophilia B in various countries worldwide, including those of the EU, as well as the USA.
Lamb, Yvette N., Hoy, Sheridan M.
openaire   +3 more sources

Real-World Use of Extended Half-Life Factor IX in Children with Haemophilia B [PDF]

Life
Introduction Limited studies have reported data on the real-world clinical use of extended half-life (EHL) IX products in children and adolescents with haemophilia B, also referred to as people with haemophilia B (PWHB).
Athina Dettoraki, Aikaterini Michalopoulou, Stefanos Saslis, Konstantina Dakou, Ioanna Stamati, Sotiria Thymianou, Zoey Kapsimali, Olympia Papakonstantinou, Helen Pergantou   +8 more
doaj   +2 more sources

Healing through faith: spirituality and shrine visitation as coping mechanisms among haemophilia patients in Kashmir—an interpretative phenomenological study [PDF]

Frontiers in Health Services
BackgroundIn Kashmir, Sufi traditions are integral to everyday life. Visits to shrines are a culturally significant expression of faith and may influence how individuals cope with lifelong health conditions such as haemophilia.ObjectiveThis study sought ...
Shabnam Mushtaq, Wakar Amin Zargar, Fayaz Ahmad Paul, Fayaz Ahmad Paul   +3 more
doaj   +2 more sources

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Haemophilia A and haemophilia B: molecular insights [PDF]

Molecular Pathology, 2002
This review focuses on selected areas that should interest both the scientist and the clinician alike: polymorphisms within the factor VIII and factor IX genes, their linkage, and their ethnic variation; a general assessment of mutations within both genes and a detailed inspection of the molecular pathology of certain mutations to illustrate the ...
openaire   +4 more sources

Haemophilia item bank based on International Classification of Functioning, Disability and Health: a systematic review

Hematology, 2023
Background and Objectives Haemophilia comprises a continuum of blood disorders that often include joint and muscular dysfunction, which may lead to a constellation of activity limitations and participation restrictions.
Bao-Feng Geng, Chun Feng, Shou-Guo Liu, Zhong-Li Jiang, Feng Lin   +4 more
doaj   +1 more source

Plasma levels of IL-1β and IL-37 in patients with severe haemophilia

Journal of International Medical Research, 2020
Objective Haemophilia A and B are disorders caused by the lack of clotting factors VIII and IX, respectively. Repeated bleeding into the same joint leads to haemophilic arthropathy (HA).
Pei-Chin Lin, Shyh-Shin Chiou, Wan-Yi Hsu, Yu-Mei Liao, Shih-Pien Tsai, Hsiu-Lan Su, Ping-Tao Lu, Yu-Hsin Tseng   +7 more
doaj   +1 more source

Haemophilia specialist nurses’ perceptions of haemophilia B

The Journal of Haemophilia Practice, 2021
Abstract Introduction Some clinicians believe that haemophilia B is associated with less bleeding than haemophilia A, yet there appears to be little difference in health-related outcomes. Current clinical practice reduces the risk of bleeds, making differences difficult to measure.
Steve Chaplin, Maj Friberg Birkedal, Erica Crilly, Simon Fletcher, Sara Garcia, Greta Mulders, Linda Myrin-Westesson, Debra Pollard, Anna Sanigorska, Nanda Uitslager   +9 more
openaire   +2 more sources

Health-related quality of life, direct medical and societal costs among children with moderate or severe haemophilia in Europe: multivariable models of the CHESS-PAEDs study

Orphanet Journal of Rare Diseases, 2022
Background Haemophilia bears substantial humanistic and economic burden on children and their caregivers. Characterising the differential impact of severe versus moderate paediatric haemophilia is important for clinical and health policy decisions.
Idaira Rodriguez-Santana, Pronabesh DasMahapatra, Tom Burke, Zalmai Hakimi, José Bartelt-Hofer, Jameel Nazir, Jamie O’Hara   +6 more
doaj   +1 more source