Results 41 to 50 of about 105,616 (269)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Resurgence of invasive Haemophilus influenzae type b disease in France, 2017–2024: epidemiological, genomic, and immunological insights

npj Vaccines
Haemophilus influenzae type b (Hib) conjugate vaccines have markedly reduced global invasive Hib disease. However, surveillance in France has shown a resurgence of Hib infections in children despite >90% vaccination coverage, coinciding with the shift ...
Nouria Belkacem, Samy Taha, Aude Terrade, Oumar Doucoure, Mélanie Denizon, Eva Hong, Michael Pruvost, Muhamed-Kheir Taha, Ala-Eddine Deghmane   +8 more
doaj   +1 more source

Comparative Genomic Analysis Reveals Genetic Diversity and Pathogenic Potential of Haemophilus seminalis and Emended Description of Haemophilus seminalis

Microbiology Spectrum, 2023
Haemophilus seminalis is a newly proposed species that is phylogenetically related to Haemophilus haemolyticus. The distribution of H. seminalis in the human population, its genomic diversity, and its pathogenic potential are still unclear.
Xiaowei Chen, Hanyun Zhang, Junhui Feng, Lei Zhang, Minling Zheng, Haimin Luo, Huiyan Zhuo, Ning Xu, Xuan Zhang, Cha Chen, Pinghua Qu, Youqiang Li   +11 more
doaj   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Haemophilus influenzae Carriage among Healthy Children in Portugal, 2015–2019

Microorganisms, 2022
Haemophilus influenzae is an important cause of mucosal and invasive infections and a common colonizer of the upper respiratory tract. As there are no recent data on H.
Maria Paula Bajanca-Lavado, Luís Cavaco, Mariana Fernandes, Tiago Touret, Catarina Candeias, Alexandra S. Simões, Raquel Sá-Leão   +6 more
doaj   +1 more source

Diabetes Mellitus Is Associated With Increased Risk for Subsequent Hip Arthroscopy After Index Hip Arthroscopy

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To determine whether diabetes mellitus is associated with higher systemic and hip‐specific complications and to evaluate reoperation rates after hip arthroscopy. Methods Using the TriNetX Research Network and Current Procedural Terminology and International Classification of Diseases codes, we identified diabetic and nondiabetic patients aged ...
Nicholas J. Morriss, Justin Harrington, Jacob Waldron, Brian Giordano   +3 more
wiley   +1 more source

Role of biofilm formation and antimicrobial resistance in urogenital Haemophilus influenzae isolates

BMC Microbiology
Background Haemophilus influenzae (Hi) is increasingly detected in genital infections in humans and linked to septic abortion. We aimed to characterize 123 non-capsulated (non-typeable) Hi isolates from genital sites in women and investigate their ...
Nouria Belkacem, Aude Terrade, Eva Hong, Ala-Eddine Deghmane, Muhamed-Kheir Taha   +4 more
doaj   +1 more source

Evaluation of VITEK 2 system and VITEK MS system for the identification of Haemophilus species: a diagnostic accuracy study

Annals of Clinical Microbiology
Background: Haemophilus is an important pathogen in community-acquired pneumonia and invasive diseases, such as sepsis and meningitis. We aimed to evaluate the VITEK 2 system and VITEK MS system for the identification of Haemophilus strains isolated from
Yeon Chan Choi, Eun-Young Kim, Hyun Jin Choi, Si Hyun Kim, Eunkyoung You, Ja Young Lee, Jihyun Cho, Seok Hoon Jeong, Dokyun Kim, Hyun Soo Kim, Soo Hyun Kim, Young Ah Kim, Young Ree Kim, Nam Hee Ryoo, Jong Hee Shin, Kyeong Seob Shin, Young Uh, Jeong Hwan Shin   +17 more
doaj   +1 more source

Comparison of the first whole genome sequence of ‘Haemophilus quentini’ with two new strains of ‘Haemophilus quentini’ and other species of Haemophilus [PDF]

, 2018
Comparison of the genome of the Gram negative human pathogen Haemophilus quentini MP1 with other Haemophilus species revealed that, although it is more closely related to Haemophilus haemolyticus than Haemophilus influenzae, the pathogen is in fact ...
Sian E.W. Davies, Hand, Daniel C., Hubbard, Alasdair T. M., Alasdair T.M. Hubbard, Cristescu, M.E., Mark M. Collery, Colin G. Fink, Fink, Colin, Laura Baxter, Baxter, Laura, Thompson, Sarah, D. John I. Thomas, Davies, Siân Elizabeth Wynne, Davies, Sian, Fink, Colin G., Hand, Daniel, Daniel C. Hand, Sarah Thompson, Collery, M., Thomas, D. John I., Collery, Mark, Thomas, Daniel John   +21 more
core   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source