Results 41 to 50 of about 51,556 (181)

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus influenzae

Genome Medicine
Background Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract and invasive infections. The emergence of β-lactamase-negative ampicillin-resistant (BLNAR) strains and unclear correlations between ...
Margo Diricks, Sabine Petersen, Lennart Bartels, Thiên-Trí Lâm, Heike Claus, Maria Paula Bajanca-Lavado, Susanne Hauswaldt, Ricardo Stolze, Omar Jiménez Vázquez, Christian Utpatel, Stefan Niemann, Jan Rupp, Inken Wohlers, Matthias Merker   +13 more
doaj   +1 more source

The first reported case of possible Haemophilus influenzae type b vaccine failure from Kuwait and literature-review

Journal of Infection and Public Health, 2014
Summary: A 17-month-old vaccinated Kuwaiti boy presented with meningitis. The Haemophilus influenzae type b (Hib) capsular antigen was detected in his blood, CSF and urine. The microorganism failed to grow in culture.
Prashant Purohit, Ina’am Ahmad Al-Obaid, Nehad Gamal Al-Deen Omar   +2 more
doaj   +1 more source

Rationale for Recommending Varicella Vaccination Into the Swedish National Immunisation Programme

Acta Paediatrica, EarlyView.
ABSTRACT Aim Under Swedish law, a vaccination may be included in the National Immunisation Programme (NIP) if it effectively prevents transmission in the population, is cost‐effective and aligns with ethical and humanitarian principles. The Public Health Agency of Sweden (PHAS) evaluated these criteria for introducing varicella vaccination. Methods The
Annika Ersson, Kari Johansen, Sören Andersson   +2 more
wiley   +1 more source

EFFICIENCY AND SAFETY OF VACCINATION AGAINST INFECTION CAUSED BY HAEMOPHILUS INFLUENZAE TYPE B AMONG INFANTS

Педиатрическая фармакология, 2008
The authors studied the results of immunization among the children against the infection caused by haemophilus influenzae type B by two vaccines: ACT HIB and Hiberix.
V.V. Botvin’eva, L.S. Namazova, A.G. Gaivoronskaya, E.G. Filyanskaya   +3 more
doaj   +2 more sources

Range of Clinical Manifestations Caused by Invasive Meningococcal Disease Due to Serogroup W: A Systematic Review

Infectious Diseases and Therapy, 2023
Introduction Invasive meningococcal disease (IMD) due to serogroup W meningococci (MenW) is consistently reported with atypical clinical manifestations, including gastrointestinal symptoms, bacteremic pneumonia, and septic arthritis.
Isabelle Bertrand-Gerentes, Laurent Fanchon, Florence Coste, Richard E. Glover, Tamazoust Guiddir, Muhamed-Kheir Taha   +5 more
doaj   +1 more source

A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors

Acta Paediatrica, EarlyView.
ABSTRACT Aims Paediatric cancer survivors often experience treatment‐induced immunosuppression, requiring post‐treatment revaccination. However, immune recovery timelines vary, and current revaccination guidelines, largely based on data of varied quality derived from studies on acute‐lymphoblastic‐leukaemia (ALL), may not be applicable across all ...
Menucha Jurkowicz, Raz Somech, Dan Dominissini, Nathan Keller, Efrat Dresner, Michal Paret, Gilad Sherman, Guy Katzenellenbogen, Elina Gelman, Keren Asraf, Ram Doolman, Atar Lev, Amos J. Simon, Helly Vernitsky, Assaf Barg, Hana Golan, Amos Toren, Michal Stein   +17 more
wiley   +1 more source

Assessing the Reduction of Recurrent Admissions Using OM‐85 for the Treatment of Preschool Wheeze (ARROW): Protocol for a Multi‐Centre, Randomised, Double‐Blind, Placebo‐Controlled Trial

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aims Acute wheezing illnesses are among the most common reasons preschool‐aged children are admitted to hospital. Readmission rates are high, and novel preventive strategies are required. OM‐85 is an orally administered bacterial lysate that stimulates anti‐viral immune responses and reduces excessive airway inflammation associated with ...
Jessica C. Costa‐Pinto, Marisa van Arragon, Katherine J. Lee, Lisa Gold, Peter D. Sly, Cameron C. Grant, Sarah McNab, Peter Vuillermin, Children's Inpatient Research Collaboration of Australia and New Zealand (CIRCAN) Investigator Group, Rebecca Alekzander, Ravichandra Balakrishnamoorthy, Sean Beggs, Habib Bhurawala, Stewart Birt, Katie Bongiolatti, Stephen Brancatisano, Blessy Charles, Roni Cole, Jessica C. Costa‐Pinto, Bailey Craig, Jacqueline Dalby‐Payne, Taya Dowling, Chris Elliot, Daniel Engleman, Wei Qi Fan, Alice Fang, Jane Fata, Catriona Fleming, Jacqueline Fradley, Jeremy Furyk, Arun Gangakhedkar, Lisa Gold, Angus Goodson, Peter Gowdie, Cameron Grant, Kelly Grant, Shehani Gunasekera, Louise Guy, Danielle Hanlon, Rachael Healey, Reena Ho, Sharon Jones, Datta Joshi, Vishal Kapoor, Jonathan Kaufman, Elizabeth Kepreotes, Annie Kilpatrick, Helena Kim, Kristy Kimlin, Christine Kwa, Julia Laing, Anita Lala, Malia Lardelli, Christine Lau, Shirley Lawrence, Katherine J. Lee, Rachel Lee, Jordan Levinter, David Levitt, Hannah Lorking, Lorraine Torrance, April Ly, Ariel Mace, Maricar Santiago Maminta, Payal Mandaliya, Natalie Martin, Brendan McCann, Timothy McDonald, Richard G. McGee, Kathryn McMahon, Sarah McNab, Kristen Mead, Tania Milne, Vasemaca Moi, Nerida Moore, Dylan Mordaunt, Tanya Newnham, Mark Norden, Kirra Philip, Maree Pigdon, Melanie Pillay, Michael Plaister, Jolene Reid, Julia Reid, Nicholas Reid, Kathryn Roberts, Maria Ronan, Thomas Saunders, Jennifer Schaefer, Rachel Schembri, Leonie Shah, Owen Sinclair, Peter Sly, Gail Spence, Jane Standish, Alicia Stanley, Simon Stokes, Scott Sypek, Laurel Teoh, Rachel Teulon, Clare Thomas, David Tickell, Laarni Tundag, Marisa Van Arragon, Peter Vuillermin, Ushma Waida, Matthew Wakeley, Alexandra Wallace, Todd Wallace, Simone Watkins, Ben Watson, Cilla Wyllie‐Schmidt, Rose Ann Yap, Helen Young, Joel Ziffer   +114 more
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source