Bacterial Vaccines and Serotype Replacement: Lessons from Haemophilus influenzae and Prospects for Streptococcus pneumoniae [PDF]
Conjugate vaccines have reduced the incidence of invasive disease caused by Haemophilus influenzae, type b (Hib), in industrialized countries and may be highly effective against Streptococcus pneumoniae.
Lipsitch, Marc
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Progress towards meningitis prevention in the conjugate vaccines era
Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in ...
Cristina Aparecida Borges Laval +4 more
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Current study aimed to estimate clinical and economic outcomes of providing the Haemophilus influenzae type b (Hib) vaccination as a national vaccine immunization program in Thailand.
Surachai Kotirum +9 more
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Haemophilus influenzae and Neisseria meningitis are gram negative, commensal bacteria naturally present in the nasopharynx. They are also naturally competent and suffer genetic mutations. H.
Izidoro Jr. M.S. +3 more
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Challenges for the development of vaccines against Haemophilus influenzae and Neisseria meningitidis
The development of protein–polysaccharide conjugate vaccines has had a major impact on Haemophilus influenzae type b disease. The application of this technology to Neisseria meningitidis is also striking, particularly for serogroup C.
Kyd, Jennelle M. +2 more
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Evaluation of an alternative informed consent procedure for clinical trials conducted in The Gambia [PDF]
Background: Comprehension of informed consent poses greater challenges to clinical trial participants in The Gambia because of low literacy and absence of standardised formats for writing the local languages.
Afolabi, MO
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Immunomodulation by microbial ribosomes
Over the past twenty years, many authors have reported evidence of the immunoprotective capacity of ribosomes isolated from bacteria, fungi and parasites.
W. Domzig +3 more
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A DTAP–IPV//PRP~T VACCINE: A REVIEW OF 16 YEARS’ CLINICAL EXPERIENCE
Owing to their low reactogenicity, confirmed efficacy and availability in combination vaccines, acellular pertussis (aP)-inactivated poliovirus (IPV) combined vaccines are now included in various national immunization programs worldwide.
Stanley A. Plotkin +3 more
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Cost effectiveness of pediatric pneumococcal conjugate vaccines: a comparative assessment of decision-making tools. [PDF]
BACKGROUND: Several decision support tools have been developed to aid policymaking regarding the adoption of pneumococcal conjugate vaccine (PCV) into national pediatric immunization programs.
A.M. Henao +31 more
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Safety and immunogenicity of an indigenously developedHaemophilus influenzaetype b conjugate vaccine through various phases of clinical trials [PDF]
Hitt Sharma +9 more
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