Results 81 to 90 of about 22,265 (286)

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

HAEMOSTATIC ABNORMALITIES IN MALARIA [PDF]

, 1993
Clinically significant bleeding is relatively uncommon in malaria and occurs in approximately 5% of patients. Severe haemostatic abnormalities are of complex origin and are manifested in thrombocytopenia, decreased activity of coagulation factors and ...
Słonecka, A., Górski, J., Nahorski, W., Birkholz, A.   +3 more
core  

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

Haemostatic therapy in spontaneous intracerebral haemorrhage patients with high-risk of haematoma expansion by CT marker: a systematic review and meta-analysis of randomised trials

Stroke and Vascular Neurology
Background and purpose Current randomised controlled trials (RCTs) showed an uncertain benefit of haemostatic therapy on preventing haematoma expansion and improving the outcome in patients with intracerebral haemorrhage (ICH). This meta-analysis aims to
Liping Liu, Yuehua Pu, Hongqiu Gu, Qi Zhou, Wenzhi Wang, Dacheng Liu, Jingyi Liu, Haixin Sun, Wanying Duan, Zhonghua Yang, Ximing Nie, Miao Wen, Shengjun Sun   +12 more
doaj   +1 more source

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source

The potential of Schistosoma-derived substances for use as basis for novel anti-haemostatic therapeutics: : A systematic review

, 2021
Background: Parasites belonging to the Schistosoma genus exert an anti-haemostatic net effect upon infection of a definitive host, despite numerous mechanisms that should be pro-haemostatic. The anti-haemostatic mechanisms are thus highly interesting, as
Li, Jonas
core   +2 more sources

Emerging haemostatic sprays: From material design to clinical translation

Haemostatic sprays have emerged as a transformative class of topical agents for the rapid control of bleeding in surgery, trauma, and endoscopy, particularly in settings where conventional approaches such as suturing, cauterisation, or mechanical ...
Nguyen, NT, Nepal, A, Tran, H, Ta, HT
core   +1 more source

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

Advanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer, Noël Strasser, Ilakkiya Ravindrarajah, Elsa Wrenger, Kristian Ivkovic, Jan Ševčík, Sima Šarčević, Lenka Červenková, Jáchym Rosendorf, Václav Liška, Alexandre H. Anthis, Thomas Rduch, Inge K. Herrmann   +12 more
wiley   +1 more source

Impaired coagulation parameters in early RA are restored by effective antirheumatic therapy: a prospective pilot study

RMD Open
Objectives To assess the effect of treatment on haemostatic parameters in patients with early rheumatoid arthritis (RA).Methods Patients with newly diagnosed RA started methotrexate and were randomised to additional conventional treatment, certolizumab ...
Ronald F van Vollenhoven, Merete Lund Hetland, Till Uhlig, Espen A Haavardsholm, Dan Nordström, Aleksandra Antovic, Mikkel Østergaard, Michael T Nurmohamed, Bjorn Gudbjornsson, Gerður Gröndal, Kim Hørslev-Petersen, Anna Rudin, Jon Lampa, Kristina Lend, Daisy Vedder, Marte Schrumpf Heiberg, Bas Dijkshoorn, Romy Hansildaar, Nida Soutari   +18 more
doaj   +1 more source

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source