Results 91 to 100 of about 11,068,075 (352)

A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability. [PDF]

PLoS ONE, 2012
Atonal homolog1 (Atoh1) is a bHLH transcription factor essential for inner ear hair cell differentiation. Targeted expression of Atoh1 at various stages in development can result in hair cell differentiation in the ear. However, the level and duration of
Ning Pan, Israt Jahan, Jennifer Kersigo, Jeremy S Duncan, Benjamin Kopecky, Bernd Fritzsch   +5 more
doaj   +1 more source

A ratchet mechanism for amplification in low-frequency mammalian hearing [PDF]

Proc. Natl. Acad. Sci. U.S.A. 107, 4973-4978 (2010), 2010
The sensitivity and frequency selectivity of hearing result from tuned amplification by an active process in the mechanoreceptive hair cells. In most vertebrates the active process stems from the active motility of hair bundles. The mammalian cochlea exhibits an additional form of mechanical activity termed electromotility: its outer hair cells (OHCs ...
arxiv   +1 more source

The very large G-protein coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles [PDF]

, 2006
Sensory hair bundles in the inner ear are composed of stereocilia that can be interconnected by a variety of different link types, including tip links, horizontal top connectors, shaft connectors, and ankle links.
Birch, David G, Goodyear, Richard J, Holt, Jeffrey R, Legan, P Kevin, Locke, Kirsten G, McGee, JoAnn, McMillan, D Randy, Richardson, Guy P, Stauffer, Eric A, Walsh, Edward J, White, Perrin C   +10 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function

Disease Models & Mechanisms, 2014
Control of the extracellular environment of inner ear hair cells by ionic transporters is crucial for hair cell function. In addition to inner ear hair cells, aquatic vertebrates have hair cells on the surface of their body in the lateral line system ...
Tamara M. Stawicki, Kelly N. Owens, Tor Linbo, Katherine E. Reinhart, Edwin W. Rubel, David W. Raible   +5 more
doaj   +1 more source

Negative membrane capacitance of outer hair cells: electromechanical coupling near resonance [PDF]

Scientific Reports 7(2017) 12118, 2017
The ability of the mammalian ear in processing high frequency sounds, up to $\sim$100 kHz, is based on the capability of outer hair cells (OHCs) responding to stimulation at high frequencies. These cells show a unique motility in their cell body coupled with charge movement.
arxiv   +1 more source

β-Catenin Is Required for Hair-Cell Differentiation in the Cochlea

Journal of Neuroscience, 2014
The development of hair cells in the auditory system can be separated into steps; first, the establishment of progenitors for the sensory epithelium, and second, the differentiation of hair cells.
Fuxin Shi, Lingxiang Hu, B. Jacques, J. Mulvaney, A. Dabdoub, A. Edge   +5 more
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle

Nature Communications
Vestibular hair cells are mechanoreceptors critical for detecting head position and motion. In mammals, hair cell loss causes vestibular dysfunction as spontaneous regeneration is nearly absent.
Tian Wang, Tian Yang, Amanda Kedaigle, Gabriela Pregernig, Ryan McCarthy, Ben Holmes, Xudong Wu, Lars Becker, Ning Pan, Kathy So, Leon Chen, Jun He, Ahmad Mahmoudi, Soumya Negi, Monika Kowalczyk, Tyler Gibson, Noah Druckenbrod, Alan G. Cheng, Joseph Burns   +18 more
doaj   +1 more source

ROOT HAIR DEFECTIVE SIX-LIKE Class I Genes Promote Root Hair Development in the Grass Brachypodium distachyon.

PLoS Genetics, 2016
Genes encoding ROOT HAIR DEFECTIVE SIX-LIKE (RSL) class I basic helix loop helix proteins are expressed in future root hair cells of the Arabidopsis thaliana root meristem where they positively regulate root hair cell development. Here we show that there
Chul Min Kim, Liam Dolan
doaj   +1 more source