Results 91 to 100 of about 11,288,087 (353)
Molecular Oncology, EarlyView.In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa +14 more
wiley +1 more source
Nature CommunicationsVestibular hair cells are mechanoreceptors critical for detecting head position and motion. In mammals, hair cell loss causes vestibular dysfunction as spontaneous regeneration is nearly absent.
Tian Wang +18 more
doaj +1 more source
NF-κB is Required for Survival of Immature Auditory Hair Cells In Vitro [PDF]
, 2018 Damage to auditory hair cells in the inner ear as a consequence of aging, disease, acoustic trauma, or exposure to ototoxins underlies most cases of hearing impairment.
Albinger-Hegyi, Andrea +4 more
core
AXR3 and SHY2 interact to regulate root hair development [PDF]
, 2003 Signal transduction of the plant hormone auxin centres on the regulation of the abundance of members of the Aux/IAA family of transcriptional regulators, of which there are 29 in Arabidopsis.
Grierson, C.S., Knox, K., Leyser, O.
core +2 more sources
β-Catenin Is Required for Hair-Cell Differentiation in the Cochlea
Journal of Neuroscience, 2014 The development of hair cells in the auditory system can be separated into steps; first, the establishment of progenitors for the sensory epithelium, and second, the differentiation of hair cells.
Fuxin Shi +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Organ of Corti and Stria Vascularis: Is there an Interdependence for Survival?
PLoS ONE, 2016 Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the stria is responsible for generating the endocochlear potential (EP), which is the driving force for
Huizhan Liu +8 more
doaj +1 more source
The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function
Disease Models & Mechanisms, 2014 Control of the extracellular environment of inner ear hair cells by ionic transporters is crucial for hair cell function. In addition to inner ear hair cells, aquatic vertebrates have hair cells on the surface of their body in the lateral line system ...
Tamara M. Stawicki +5 more
doaj +1 more source
Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss [PDF]
, 2005 The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells.
Arntz, Claudia +18 more
core
Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons [PDF]
, 2014 The hyperpolarization-activated, cyclic nucleotide–sensitive current, Ih, is present in vestibular hair cells and vestibular ganglion neurons, and is required for normal balance function.
Holt, Jeffrey R. +2 more
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