Results 121 to 130 of about 11,068,075 (352)

Transcriptomic characterization of dying hair cells in the avian cochlea

Cell Reports, 2021
Summary: Sensory hair cells are prone to apoptosis caused by various drugs including aminoglycoside antibiotics. In mammals, this vulnerability results in permanent hearing loss because lost hair cells are not regenerated.
Nesrine Benkafadar, Amanda Janesick, Mirko Scheibinger, Angela H. Ling, Taha A. Jan, Stefan Heller   +5 more
doaj  

Suppression of Inflammation Delays Hair Cell Regeneration and Functional Recovery Following Lateral Line Damage in Zebrafish Larvae

Biomolecules, 2020
Cochlear hair cells in human beings cannot regenerate after loss; however, those in fish and other lower species can. Recently, the role of inflammation in hair cell regeneration has been attracting the attention of scientists.
Ru Zhang, Xiaopeng Liu, Yajuan Li, Ming Wang, Lin Chen, Bing Hu   +5 more
doaj   +1 more source

Multifrequency Forcing of a Hopf Oscillator Model of the Inner Ear [PDF]

, 2007
In response to a sound stimulus, the inner ear emits sounds called otoacoustic emissions. While the exact mechanism for the production of otoacoustic emissions is not known, active motion of individual hair cells is thought to play a role. Two possible sources for otoacoustic emissions, both localized within individual hair cells, include somatic ...
arxiv   +1 more source

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

Nature Communications, 2017
Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen–anagen transition (TAT) around the ...
Xusheng Wang, Haiyan Chen, Ruiyun Tian, Yiling Zhang, M. Drutskaya, Chengmei Wang, Jianfeng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jinmei Wang, Shan Wang, Zhihai Qin, Huan-huan Jia, Yu'e Wu, Jia Liu, S. Nedospasov, E. Tredget, Mei Lin, Jianjun Liu, Yuyang Jiang, Yaojiong Wu   +24 more
semanticscholar   +1 more source

Data‐driven forecasting of ship motions in waves using machine learning and dynamic mode decomposition

International Journal of Adaptive Control and Signal Processing, EarlyView.
Summary Data‐driven forecasting of ship motions in waves is investigated through feedforward and recurrent neural networks as well as dynamic mode decomposition. The goal is to predict future ship motion variables based on past data collected on the field, using equation‐free approaches.
Matteo Diez, Mauro Gaggero, Andrea Serani   +2 more
wiley   +1 more source

Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells [PDF]

, 2017
Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to obtain large numbers of cochlear hair cells.
Edge, Albert S.B., Karp, Jeffrey M., Langer, Robert S, Lenz, Danielle R., Lu, Lin, McLean, Dalton, McLean, Will J., Yin, Xiaolei   +7 more
core   +2 more sources

Cell-Specific Transcriptome Analysis Shows That Adult Pillar and Deiters' Cells Express Genes Encoding Machinery for Specializations of Cochlear Hair Cells

Frontiers in Molecular Neuroscience, 2018
The mammalian auditory sensory epithelium, the organ of Corti, is composed of hair cells and supporting cells. Hair cells contain specializations in the apical, basolateral and synaptic membranes.
Huizhan Liu, Lei Chen, Kimberlee P. Giffen, Sean T. Stringham, Yi Li, Paul D. Judge, K. Beisel, D. He   +7 more
semanticscholar   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function

eLife, 2019
To support cell survival, mitochondria must balance energy production with oxidative stress. Inner ear hair cells are particularly vulnerable to oxidative stress; thus require tight mitochondrial regulation.
Mroj Alassaf, Emily C Daykin, Jaffna Mathiaparanam, Marc A Wolman   +3 more
doaj   +1 more source

On size and growth of cells [PDF]

arXiv, 2002
Understanding how growth induces form is a longstanding biological question. Many studies concentrated on the shapes of plant cells, fungi or bacteria. Some others have shown the importance of the mechanical properties of bacterial walls and plant tissues in pattern formation. Here I sketch a simple physical picture of cell growth.
arxiv