Results 291 to 300 of about 554,359 (356)

Rescue of cochlear vascular pathology prevents sensory hair cell loss in Norrie disease. [PDF]

Proc Natl Acad Sci U S A
Patel A, Pauzuolyte V, Ingham NJ, Leong YC, Berger W, Steel KP, Sowden JC.   +6 more
europepmc   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing loss. [PDF]

Exp Mol Med
Jung J, Joo SY, Min H, Roh JW, Kim KA, Ma JH, Rim JH, Kim JA, Kim SJ, Jang SH, Koh YI, Kim HY, Lee H, Kim BC, Gee HY, Bok J, Choi JY, Seong JK.   +17 more
europepmc   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Conditional Overexpression of Neuritin in Supporting Cell Protects Cochlear Hair Cell and Delays Age-Related Hearing Loss by Enhancing Autophagy. [PDF]

Int J Mol Sci
Wang S, Lv S, Hu J, Shi Y, Li Y, Zhang J, Tan X, Chen R, Hong Y.   +8 more
europepmc   +1 more source

Hair cell regeneration in vestibular epithelia : a study in an in vitro model

, 2016
Mimmi Werner
openalex   +1 more source

Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells

Advanced Science, EarlyView.
The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Achille Joliot, Laure Stickel, Pascal Martin   +2 more
wiley   +1 more source

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. [PDF]

Elife
Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Aponte Rivera R, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, Sotomayor M, Ahmed ZM.   +16 more
europepmc   +1 more source

Chemically defined and dynamic click hydrogels support hair cell differentiation in human inner ear organoids. [PDF]

Stem Cell Reports
Arkenberg MR, Jafarkhani M, Lin CC, Hashino E.   +3 more
europepmc   +1 more source

Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current. [PDF]

Sci Rep
Zhu Z, Reid W, Ó Maoiléidigh D.
europepmc   +1 more source