Results 301 to 310 of about 10,895,649 (358)
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Capturing and profiling adult hair follicle stem cells
Nature Biotechnology, 2004Jamie S Lin +2 more
exaly +2 more sources
Current Opinion in Neurobiology, 1993
Neurobiologists have been challenged by the desire to understand how the highly specialized ultrastructure of the sensory hair cells of the ear develops, how patterns of phenotypically distinct hair cells are formed and regenerate, and how their specific neural connections are formed.
Jeffrey T. Corwin +2 more
openaire +2 more sources
Neurobiologists have been challenged by the desire to understand how the highly specialized ultrastructure of the sensory hair cells of the ear develops, how patterns of phenotypically distinct hair cells are formed and regenerate, and how their specific neural connections are formed.
Jeffrey T. Corwin +2 more
openaire +2 more sources
How hair cells hear: the molecular basis of hair-cell mechanotransduction
Current Opinion in Otolaryngology & Head & Neck Surgery, 2008This review aims to summarize our current knowledge regarding mechanotransduction by hair cells and to highlight unresolved questions.Despite over a quarter of a century of electrophysiological data describing hair-cell mechanotransduction, the molecular basis of this process is just now being revealed.
Kelli R. Phillips +2 more
openaire +3 more sources
2019
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss.
Huawei Li +4 more
openaire +3 more sources
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss.
Huawei Li +4 more
openaire +3 more sources
Development and regeneration of hair cells
Acta Oto-Laryngologica, 2007The vertebrate inner ear is derived from the otic placode and undergoes a complicated series of morphogenetic processes to differentiate into an elaborate structure harboring mechanosensory epithelia featuring hair cells, the mechanoreceptors of hearing and balance.
Ozeki, Hidenori +4 more
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The Electrophysiology of Hair Cells
Annual Review of Physiology, 1991Both the hearing and vestibular organs of vertebrates contain cells responsive to miniscule mechanical disturbances. The common element is the hair cell, a sensory cell with a specialized mechanoreceptor at its apical end and with a basolateral membrane designed to shape the receptor potential and control synaptic interaction at its basal pole. The way
openaire +3 more sources
Annual Review of Neuroscience, 2000
Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
openaire +3 more sources
Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
openaire +3 more sources
Hearing Research, 1990
This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Prosen, Cynthia A. +7 more
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This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Prosen, Cynthia A. +7 more
openaire +4 more sources
Seminars in Cell & Developmental Biology, 2007
The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
Colin A.B. Jahoda +2 more
openaire +2 more sources
The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
Colin A.B. Jahoda +2 more
openaire +2 more sources
Experimental Dermatology, 2019
Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP‐derived Exos, especially those ...
M. Kwack +6 more
semanticscholar +1 more source
Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP‐derived Exos, especially those ...
M. Kwack +6 more
semanticscholar +1 more source