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2019
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss.
Huawei Li +4 more
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Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss.
Huawei Li +4 more
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Development and regeneration of hair cells
Acta Oto-Laryngologica, 2007The vertebrate inner ear is derived from the otic placode and undergoes a complicated series of morphogenetic processes to differentiate into an elaborate structure harboring mechanosensory epithelia featuring hair cells, the mechanoreceptors of hearing and balance.
Ozeki, Hidenori +4 more
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The Electrophysiology of Hair Cells
Annual Review of Physiology, 1991Both the hearing and vestibular organs of vertebrates contain cells responsive to miniscule mechanical disturbances. The common element is the hair cell, a sensory cell with a specialized mechanoreceptor at its apical end and with a basolateral membrane designed to shape the receptor potential and control synaptic interaction at its basal pole. The way
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Annual Review of Neuroscience, 2000
Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
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Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
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Experimental Dermatology, 2019
Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP‐derived Exos, especially those ...
M. Kwack +6 more
semanticscholar +1 more source
Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP‐derived Exos, especially those ...
M. Kwack +6 more
semanticscholar +1 more source
Hearing Research, 1990
This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Prosen, Cynthia A. +7 more
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This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Prosen, Cynthia A. +7 more
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Mechanoelectrical Transduction by Hair Cells [PDF]
Annual Review of Biophysics and Biophysical Chemistry, 1988 STRUCTURE AND STIMULATION OF THE HAIR BUNDLE 100 Structure of the Hair Bundle.... ......... .. . . . .... . . . . . . . . . . . . . . . . . . . . . .. . . . . . 100 Mechanical Properties of the Hair Bundle ....... ......... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
William M. Roberts +2 more
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Evoked mechanical responses of isolated cochlear outer hair cells.
Science, 1985Intracellular current administration evokes rapid, graded, and bidirectional mechanical responses of isolated outer hair cells from the mammalian inner ear.
W. Brownell +3 more
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Seminars in Cell & Developmental Biology, 2007
The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
Colin A.B. Jahoda +2 more
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The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
Colin A.B. Jahoda +2 more
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Immunolocalization of myosin Iβ in the hair cell's hair bundle
Cell Motility and the Cytoskeleton, 1998The hair bundle, the hair cell's sensory organelle, transduces acoustical or vestibular stimulation into a change in membrane potential. The actin-based stereociliary processes of the hair bundle contain a number of myosin isoforms that may be important to the bundle's function.
Anne B. Metcalf, Anne B. Metcalf
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