Results 351 to 360 of about 10,997,299 (381)
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International Congress Series, 2003
Abstract Hair cell loss is usually a function of age, noise, ototoxic drugs and genetics. Therapeutic strategies fall into two categories: protection and regeneration. Protective methods include targeted application of growth factors and other agents to promote cell survival, and systemic application of drugs to prevent activation of programmed cell ...
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Abstract Hair cell loss is usually a function of age, noise, ototoxic drugs and genetics. Therapeutic strategies fall into two categories: protection and regeneration. Protective methods include targeted application of growth factors and other agents to promote cell survival, and systemic application of drugs to prevent activation of programmed cell ...
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MECHANISMS OF HAIR CELL TUNING
Annual Review of Physiology, 1999▪ Abstract Mechanosensory hair cells of the vertebrate inner ear contribute to acoustic tuning through feedback processes involving voltage-gated channels in the basolateral membrane and mechanotransduction channels in the apical hair bundle. The specific number and kinetics of calcium-activated (BK) potassium channels determine the resonant ...
Paul A. Fuchs, Robert Fettiplace
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Vesicle Targeting in Hair Cells
Audiology and Neurotology, 2002The mammalian hair cell has two distinct plasma membrane domains separated by tight junctions, the apical domain which contains the stereocilia and the basolateral domain which contains the presynaptic region. Little is known concerning the mechanisms that regulate vesicle trafficking to these two domains.
Bechara Kachar +7 more
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2006
Vertebrate Hair Cells: Modern and Historic Perspectives.- The Development of Hair Cells in the Inner Ear.- The Structure and Composition of the Stereociliary Bundle of Vertebrate Hair Cells.- Mechanoelectrical Transduction in Auditory Hair Cells.- Contribution of Ionic Currents to Tuning in Auditory Hair Cells.- The Synaptic Physiology of Hair Cells ...
Richard R. Fay +2 more
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Vertebrate Hair Cells: Modern and Historic Perspectives.- The Development of Hair Cells in the Inner Ear.- The Structure and Composition of the Stereociliary Bundle of Vertebrate Hair Cells.- Mechanoelectrical Transduction in Auditory Hair Cells.- Contribution of Ionic Currents to Tuning in Auditory Hair Cells.- The Synaptic Physiology of Hair Cells ...
Richard R. Fay +2 more
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Models of Hair Cell Mechanotransduction
2007Hair cell mechanotransduction is based on a finely tuned machinery residing in the hair bundle, the hair cell's receptive organelle. The machinery consists of a transduction channel, an adaptation motor, the tip link, and many other components that reside in the stereocilia.
Jonathon Howard, Susanne Bechstedt
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Functional Development of Hair Cells
2003Abstract Embryonic hair cells in chicks and mammals have functional transduction channels and voltage-gated outwardly rectifying potassium (K + ) channels, fast inwardly rectifying channels, and voltage-gated sodium (Na + ) and calcium (Ca 2+ ) channels.
Ruth Anne Eatock, Karen M. Hurley
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Annals of Otology, Rhinology & Laryngology, 2000
The sensory hair cells of the inner ear are responsible for converting balance and hearing stimuli into electrical signals. Until recently, all previous studies of hair cell physiology had been performed on tissue obtained from non-mammals and rodents.
Ruth Anne Eatock +7 more
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The sensory hair cells of the inner ear are responsible for converting balance and hearing stimuli into electrical signals. Until recently, all previous studies of hair cell physiology had been performed on tissue obtained from non-mammals and rodents.
Ruth Anne Eatock +7 more
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Hair Cells – Beyond the Transducer
Journal of Membrane Biology, 2006This review considers the "tween twixt and twain" of hair cell physiology, specifically the signaling elements and membrane conductances which underpin forward and reverse transduction at the input stage of hair cell function and neurotransmitter release at the output stage. Other sections of this review series outline the advances which have been made
Gary D. Housley +3 more
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Math1: an essential gene for the generation of inner ear hair cells.
Science, 1999The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion.
N. Bermingham +8 more
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