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The hair cell's transduction channel

Current Opinion in Neurobiology, 2002
The elusive transduction channel is the key player in mechanical transduction by the sensory hair cells of the inner ear. Multiple factors have thwarted molecular identification of this channel, including the lack of a definitive pharmacological signature, the paucity of hair cells, and the uniqueness of their transduction mechanism. At present, we are
Meredith Strassmaier, Peter G. Gillespie
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Hair Cells and Their Synapses

2017
The peripheral auditory system acts like a spectrum analyzer to break down complex sounds into their frequency and intensity components. All of this information is transferred from sensory cell to afferent fiber via ribbon synapses where graded hair cell receptor potentials are transformed into synaptic events that generate postsynaptic action ...
Michael E. Schnee, Anthony J. Ricci
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Vestibular hair cells and afferents: two channels for head motion signals.

Annual Review of Neuroscience, 2011
Vestibular epithelia of the inner ear detect head motions over a wide range of amplitudes and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of vestibular epithelia form distinct populations with different response ...
R. Eatock, J. Songer
semanticscholar   +1 more source

Mechanoelectrical transduction by hair cells

Trends in Neurosciences, 1992
Hair cells of the inner ear are one of nature's great success stories, appearing early in vertebrate evolution and having a similar form in all vertebrate classes. They are specialized columnar epithelial cells, with an array of modified microvilli or stereocilia on their apical surface, interconnected by a series of linkages.
David P. Corey, James O. Pickles
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The aging vestibular hair cell

American Journal of Otolaryngology, 1983
The ultrastructure of aging vestibular hair cells of the guinea pig can be abnormal even though they appear morphologically normal by light microscopy. In only a few of the hair cells studied did nonspecific changes occur. In general, the age-related changes involved specific structures in the hair cells: aggregations of lipofuscin pigments ...
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The Hair Cell Synapse

2011
The sensory cells of the auditory/vestibular system rely on two highly specialized structures to transmit information to the brain: hair bundles and ribbon synapses. Hair bundles transduce sound and head movements into changes in membrane potential, which in turn stimulate ribbon synapses to release neurotransmitter.
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Cytodifferentiation of cochlear hair cells

American Journal of Otolaryngology, 1983
Cytodifferentiation of a limited number of cochlear hair cells in the mouse starts on the 14th gestational day. One day later, the number of identified hair cells increases considerably. Cytodifferentiation apparently occurs in a gradient from the hair cell surface to the base.
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A study of the medullary cells of the hair

Experimental Cell Research, 1953
Abstract 1. 1. Medullary cells of white rabbit hair were isolated by a modified method of Lloyd and Marriott. 2. 2. Microscopic examination of isolated medullary cells shows that they are made up of both large and small granules. Medullary cells appear isotropic under the polarizing microscope.
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Hair Follicle Stem Cells and Hair Regeneration

2020
Sung-Jan Lin   +5 more
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