Results 201 to 210 of about 1,572,967 (270)

Efficient Endolymphatic Sac-Directed Gene Delivery Using AAV8BP2 and Posterior Semicircular Canal Injection. [PDF]

Int J Mol Sci
Kang M, Suh MJ, Gee HY, Chien WW, Jung J.   +4 more
europepmc   +1 more source

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

Prevalence of Thyroid Dysfunction in Patients With Chronic Spontaneous Urticaria Attending a Tertiary Care Urticaria Clinic: A Cross-Sectional Study. [PDF]

Cureus
Srinivasan V, Kannan R, Vadivelu S.
europepmc   +1 more source

Baseline podocyte‐associated state and persistent cell–matrix transcriptional programs are associated with BALB/c substrain differences in adriamycin nephropathy

Animal Models and Experimental Medicine, EarlyView.
Two closely related BALB/c substrains exhibit different early responses to adriamycin (ADR)‐induced nephropathy. BALB/cByJcl mice showed lower baseline WT1‐positive nuclei counts and NPHS1 immunoreactivity than BALB/cAJcl mice, together with extracellular matrix and integrin programs that were enriched at baseline and persisted at Day 5.
Ryuya Nakagawa, Masaki Watanabe, Koyuki Kawamoto, Momoka Hiratsuka, Takeru Sasaki, Nobuya Sasaki   +5 more
wiley   +1 more source

Silent Trichophagia Behind Visible Trichotillomania: A Case Report of a Giant Gastric Trichobezoar in an Adolescent With Intellectual Disability and Anemophobia. [PDF]

Cureus
Belaziz F, Koreda H, Benkarroum F, Moussaoui J, Barrimi M.   +4 more
europepmc   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

A decade of hair-loss clinical trials: a registry-based analysis of studies registered on ClinicalTrials.gov. [PDF]

Front Med (Lausanne)
Parra-Guerra AD, Sánchez-Dueñas LE, Quintero-Loreto ML, Quinoñes-Hernández DG, Moreno-Alanis JA, González FKS, Cavazos CJR, Mendoza DG, Villarreal-Villarreal CD, Chejfec-Ciociano JM.   +9 more
europepmc   +1 more source

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

CCDC181, a kinocilium-localization protein, is dispensable for hair bundle development and auditory perception. [PDF]

Neurosci Lett
Liu C, Nahornyi R, Li J, Oh SI, Zhao B.
europepmc   +1 more source

Successful treatment of coexisting alopecia areata and hidradenitis suppurativa with upadacitinib. [PDF]

An Bras Dermatol
Moreira Gomes P, Costa R, Pedrosa A, Lisboa C.   +3 more
europepmc   +1 more source