Results 21 to 30 of about 429,150 (378)

Circ 0020938 inhibits hair follicle stem cells proliferation via the miR-142-5p/DSG4 axis in cashmere goats. [PDF]

BMC Genomics
Background Shaanbei white cashmere goat is an excellent cashmere goat breed, and its market favored cashmere from the secondary hair follicles. Hair follicles mature around birth and each hair follicle repeatedly undergoes a growth cycle that comprises ...
Du J, Sui M, Song Z, Liang S, Zheng Y, Wang X.   +5 more
europepmc   +2 more sources

Identification of N6-Methyladenosine-Related Factors and the Prediction of the Regulatory Mechanism of Hair Follicle Development in Rex and Hycole Rabbits

Biology, 2023
Hair follicle development directly affects the development of the rabbit fur industry. The growth and development of a hair follicle is modified and regulated by many genes and mechanisms. M6A is an important RNA modification.
Gang Luo, Ruiguang Gong, Yaotian Ai, Tongyan Zhu, Zhanjun Ren   +4 more
doaj   +1 more source

Gene network analysis reveals candidate genes related with the hair follicle development in sheep

BMC Genomics, 2022
Background Merino sheep are the most famous fine wool sheep in the world. They have high wool production and excellent wool quality and have attracted worldwide attention. The fleece of the Merino sheep is composed predominantly of wool fibers grown from
Junmin He, Bingru Zhao, Xixia Huang, Xuefeng Fu, Guifen Liu, Yuezhen Tian, Cuiling Wu, Jingyi Mao, Jing Liu, Shuangbao Gun, Kechuan Tian   +10 more
doaj   +1 more source

Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway

Acta Biochimica et Biophysica Sinica, 2023
Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration. However, it is not clear whether recombinant
Chen Yijun, Lu Zhujin, Feng Jiaxin, Chen Zefeng, Liu Zejian, Wang Xiuqi, Yan Huichao, Gao Chunqi   +7 more
doaj   +1 more source

Hair follicle immune privilege and its collapse in alopecia areata

Experimental Dermatology, 2020
Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge downwards to the bulb. Both passive and active IP mechanisms protect HFs from physiologically undesired immune responses and limit immune surveillance.
M. Bertolini, K. McElwee, A. Gilhar, S. Bulfone-Paus, R. Paus   +4 more
semanticscholar   +1 more source

Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration

Journal of Biomedical Sciences, 2020
Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem cell niche has evolved with multifunctionality
Chih-Lung Chen, Wen-Yen Huang, E. Wang, K. Tai, Sung-Jan Lin   +4 more
semanticscholar   +1 more source

Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles [PDF]

, 2007
The transcription factor Gata3 is crucially involved in epidermis and hair follicle differentiation. Yet, little is known about how Gata3 co-ordinates stem cell lineage determination in skin, what pathways are involved and how Gata3 differentially ...
Doorninck, J.H. (Hikke) van, Garinis, G.A. (George), Grosveld, F.G. (Frank), Kurek, D. (Dorota), Wees, J. (Jacqueline) van der   +4 more
core   +8 more sources

PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration

Stem cell research & therapeutics, 2020
Cultured epidermal stem cells (Epi-SCs) and skin-derived precursors (SKPs) were capable of reconstituting functional hair follicles after implantation, while the signaling pathways that regulate neogenic hair follicle formation are poorly investigated ...
Yu Chen, Zhimeng Fan, Xiaoxiao Wang, Miaohua Mo, Shuxian Zeng, R. Xu, Xusheng Wang, Yaojiong Wu   +7 more
semanticscholar   +1 more source

Immune modulation of hair follicle regeneration

npj Regenerative Medicine, 2020
The mammalian hair follicle undergoes repeated bouts of regeneration orchestrated by a variety of hair follicle stem cells. The last decade has witnessed the emergence of the immune niche as a key regulator of stem cell behavior and hair follicle ...
Waleed Rahmani, S. Sinha, J. Biernaskie
semanticscholar   +1 more source

The dermal sheath: An emerging component of the hair follicle stem cell niche

Experimental Dermatology, 2020
Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle growth, which are periodically interrupted by follicle ...
P. Martino, N. Heitman, Michael Rendl
semanticscholar   +1 more source