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Dynamic Signals for Hair Follicle Development and Regeneration
Stem Cells and Development, 2012Hair follicles form during embryonic development and, after birth, undergo recurrent cycling of growth, regression, and relative quiescence. As a functional mini-organ, the hair follicle develops in an environment with dynamic and alternating changes of diverse molecular signals. Over the past decades, genetically engineered mouse models have been used
Xusheng, Wang +2 more
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Embryonic development of hair follicle pluripotent stem (hfPS) cells
Medical Molecular Morphology, 2010Our laboratory discovered nestin-expressing hair follicle stem cells and demonstrated their pluripotency. We have shown that nestin-positive and K15-negative multipotent hair follicle stem cells are located above the hair follicle bulge, and we termed these cells hair follicle pluripotent stem (hfPS) cells.
Yasuyuki, Amoh +3 more
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Overexpression of Fgf8 in the epidermis inhibits hair follicle development
Experimental Dermatology, 2020AbstractThe hair follicle is a classical model for studying epithelial–mesenchymal interactions. Given the critical role of fibroblast growth factor 8 (Fgf8) in embryonic development, we generated a mouse model that overexpresses Fgf8 specifically in the epidermis.
Zhengsen Wang +3 more
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Development of in vitro hair pigmentation model using hair follicle organoids
Journal of Bioscience and BioengineeringHair color is formed through a series of processes such as melanin synthesis and storage in melanosomes, transfer from melanocytes, and reception by hair matrix cells in the hair bulb. Because gray hair is caused by the deterioration of a single or multiple of these processes, understanding the mechanisms responsible for these processes is crucial for ...
Shan Tu +4 more
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Sox13 is a novel early marker for hair follicle development
Biochemical and Biophysical Research Communications, 2019Sox13, a group D member of the Sry-related high-mobility group box (Sox) transcription factor family, is expressed in various tissues including the hair follicle. However, its spatiotemporal expression patterns in the hair follicle and its role in hair development remain to be elucidated.
Mai Noto +9 more
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Thymosin β4 promotes angiogenesis, wound healing, and hair follicle development
Mechanisms of Ageing and Development, 2004New blood vessel formation is important in many physiological process, including development, wound repair, and tumor growth. In aged animals, angiogenesis is reduced resulting in poor wound healing. We have identified a novel small molecule, thymosin beta(4), that promotes angiogenesis and wound repair in both normal and aged rodents. It also promotes
D, Philp, A L, Goldstein, H K, Kleinman
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Formation of cornified cell envelope in human hair follicle development
British Journal of Dermatology, 2002Cornified cell envelope (CCE) formation is an important step in the final stage of keratinization, in which CCE precursor proteins including involucrin and loricrin are cross-linked by keratinocyte transglutaminases (TGases) to the inner surface of the plasma membrane of cornified cells, while the outer surface is coated with material derived from ...
M, Akiyama, I, Matsuo, H, Shimizu
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[Hoxc13 and the development of hair follicle].
Yi chuan = Hereditas, 2010Hoxc13 belongs to the Abd-B class of Hox gene family, which participated in the hair follicle formation and hair growth regulation process. The structural protein of hair KP (keratin) and KAP (keratin-associated protein) expression is under regulation of Hoxc13, and then changes the characteristics of hair by regulating the composition of these two ...
Jiang-Hong, Wu +4 more
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Proteoglycans and Glycoproteins in Hair Follicle Development and Cyclinga
Annals of the New York Academy of Sciences, 1991Udgivelsesdato: 1991-Dec ...
Couchman, J R, McCarthy, K J, Woods, A
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Epimorphin expression during human foetal hair follicle development.
The British journal of dermatology, 2000Epimorphin is a mesenchymal protein expressed in several organs and known to have an essential role in epithelial tissue organization, including hair follicle morphogenesis, in mice. Although about 90% homology has been reported between human and mouse epimorphin exon sequences, there is no information about expression and function of epimorphin in ...
M, Akiyama +5 more
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