Results 241 to 250 of about 32,165 (298)

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

Relevance of topical application of minoxidil laden nano-lipid for hair growth enhancement. [PDF]

Saudi Pharm J
Alghazal AM, Shehata TM, Alduhbiab B, Elsewedy HS.   +3 more
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Contact Allergy to Ingredients of Hair Cosmetics Associated with Occupational and Non-Occupational Exposure-Trends from 1995 to 2020 in Central Europe, with or without Regulation. [PDF]

Contact Dermatitis
Uter W, Schwensen JFB, Blömeke B, Gefeller O, John SM, Bieck C, Schubert S.   +6 more
europepmc   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

The risks of hormones to the inner ear. [PDF]

Braz J Otorhinolaryngol
Mangia LRL, Mezzalira R, Bittar RSM.
europepmc   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE)-Like Presentation in a Case of Systemic Contact Dermatitis to Paraphenylenediamine (PPD). [PDF]

Cureus
Sushantika S, Nanda S, Sethi J, Phulware RH.   +3 more
europepmc   +1 more source

Emerging pharmacotherapies and regenerative solutions for promoting hair growth for androgenetic alopecia. [PDF]

Front Pharmacol
Burshtein J, Burshtein A, Schlesinger T.
europepmc   +1 more source

Cytotoxic Drug Handling Practices Among Pharmacy Technicians in Portugal: The Dig Deeper Study. [PDF]

Healthcare (Basel)
Reis A, Silva V, Joaquim JJ, Matos C, Valeiro C, Freitas C, Pereira OR, Mateos-Campos R, Moreira F.   +8 more
europepmc   +1 more source