Results 91 to 100 of about 59,552 (223)

Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme.

RNA: A publication of the RNA Society, 2009
Despite numerous structural and biochemical investigations, the catalytic mechanism of hairpin ribozyme self-cleavage remains elusive. To gain insight into the coupling of active site dynamics with activity of this small catalytic RNA, we analyzed a ...

semanticscholar   +1 more source

Measuring the energy landscape roughness and the transition state location of biomolecules using single molecule mechanical unfolding experiments

, 2006
Single molecule mechanical unfolding experiments are beginning to provide profiles of the complex energy landscape of biomolecules. In order to obtain reliable estimates of the energy landscape characteristics it is necessary to combine the experimental ...
Changbong Hyeon, D Thirumalai, Derenyi I, Evans E, Fisher T E, Hummer G, Lide D R, Lu H, Ritort F, Zwanzig R   +9 more
core   +1 more source

Ribozymes [PDF]

, 2009
Ribozimi su katalitičke molekule koje moraju biti savijene u visoko uređene tercijarne strukture, kao što to proteini rade da bi obavljali svoje funkcije. Glavni cilj je dovesti nukleofil i izrezujući fosfat u blizinu i aktivirati ih.
Zoko, Nikolina
core   +2 more sources

Metal Ions Play a Passive Role in the Hairpin Ribozyme Catalysed Reaction [PDF]

, 1997
Karen J. Young, F. Gill, Jane A. Grasby
openalex   +1 more source

Folding of the Hairpin Ribozyme in Its Natural Conformation Achieves Close Physical Proximity of the Loops [PDF]

, 1998
Alastair I.H. Murchie, James B. Thomson, Frank Walter, David M.J. Lilley   +3 more
openalex   +1 more source

Mini-ribozymes and freezing environment: a new scenario for the early RNA world

, 2005
International audienceThe RNA World hypothesis states that the present-day life, which is based on DNA genomes and protein enzymes, was preceded by a simpler life form based primarily on RNA.
Vlassov, A. V.
core   +1 more source

RNA double cleavage by a hairpin-derived twin ribozyme [PDF]

, 2000
Christian Schmidt
openalex   +1 more source

Identification of over 200-fold more hairpin ribozymes than previously known in diverse circular RNAs [PDF]

, 2021
Christina E. Weinberg, V Janett Olzog, Iris Eckert, Zasha Weinberg   +3 more
openalex   +1 more source

Mg2+-independent hairpin ribozyme catalysis in hydrated RNA films [PDF]

, 2000
Attila A. Seyhan, John M. Burke
openalex   +1 more source

NMR structure of the A730 loop of the Neurospora VS ribozyme: insights into the formation of the active site [PDF]

The Neurospora VS ribozyme is a small nucleolytic ribozyme with unique primary, secondary and global tertiary structures, which displays mechanistic similarities to the hairpin ribozyme.
Alam, Allain, Andersen, Beattie, Boisbouvier, Brutscher, Butcher, Butcher, Cai, Campbell, Campbell, Cate, Clore, Cochrane, Collins, Collins, Correll, Delaglio, Dingley, Dosset, Elder, Emsley, Eric Bonneau, Flinders, Flinders, Geneviève Desjardins, Grzesiek, Guo, Guo, Hansen, Hermann, Heus, Hiley, Hiley, Hoffmann, Ikura, Jaikaran, Johnson, Jones, Jucker, Jérôme Boisbouvier, Lafontaine, Lafontaine, Lafontaine, Lafontaine, Lavery, Legault, Legault, Legault, Leontis, Leontis, Lilley, Lilley, Lipfert, Michiels, Moody, Mueller, Nicolas Girard, Pascale Legault, Pearlman, Piotto, Pyle, Rance, Rastogi, Rastogi, Ravindranathan, Rupert, Rupert, Saville, Schwalbe, Schwieters, Smith, Smith, Smith, Sood, Sood, Szewczak, Van Melckebeke, Walter, Wijmenga, Wilson, Wilson, Wimberly, Zhang, Zhao, Zimmermann   +85 more
core   +2 more sources