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Characterization of hairpin ribozyme reactions.
Methods in molecular biology, 2014Hairpin ribozymes are small RNA catalytic motifs naturally found in the satellite RNAs of tobacco ringspot virus (TRsV), chicory yellow mottle virus (CYMoV), and arabis mosaic virus (ArMV). The catalytic activity of the hairpin ribozyme extends to both cleavage and ligation reactions.
P. Bajaj, C. Hammann
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Elucidating the Self-cleavage Dynamics of Hairpin Ribozyme by Mode-decomposed Infrared Spectroscopy.
Journal of Physical Chemistry Letters, 2023While catalytic reactions of biomolecular processes play an indispensable role in life, extracting the underlying molecular picture often remains challenging.
Adnan Gulzar +3 more
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Deciphering the Self-Cleavage Reaction Mechanism of Hairpin Ribozyme.
Journal of Physical Chemistry B, 2020Hairpin ribozyme catalyzes the reversible self-cleavage of phosphodiester bonds which plays prominent roles in key biological processes involving RNAs. Despite impressive advances on ribozymatic self-cleavage, critical aspects of its molecular reaction ...
Narendra Kumar, D. Marx
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On the Adaptability of the Chemical Reaction of Hairpin Ribozyme to High Pressures.
Journal of Physical Chemistry Letters, 2020The discovery of RNA enzymes, ribozymes, provided strong support to the RNA world hypothesis suggesting that early life evolved from RNAs able to both store genetic information and catalyze biochemical reactions.
Narendra Kumar, D. Marx
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Kinetic characterization of hairpin ribozyme variants. [PDF]
Methods in molecular biology, 2012 Kinetic analysis of ribozyme reactions is a common method to evaluate and compare activities of catalytic RNAs. The hairpin ribozyme catalyzes the reversible cleavage of a suitable RNA substrate at a specific site. Hairpin ribozyme variants as an allosteric ribozyme responsive to flavine mononucleotide and a hairpin-derived twin ribozyme that catalyzes
Bettina Appel +3 more
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Methods, 1993
Abstract The hairpin ribozyme is a catalytic RNA capable of specifically cleaving a variety of substrate RNA sequences in either a cis or a trans reaction. The trans reaction has favorable catalytic and physical properties that make this ribozyme a potentially powerful in vivo regulator of gene expression.
Steven Nesbitt +3 more
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Abstract The hairpin ribozyme is a catalytic RNA capable of specifically cleaving a variety of substrate RNA sequences in either a cis or a trans reaction. The trans reaction has favorable catalytic and physical properties that make this ribozyme a potentially powerful in vivo regulator of gene expression.
Steven Nesbitt +3 more
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The hairpin ribozyme: structure, assembly and catalysis [PDF]
Current Opinion in Chemical Biology, 1998 Recent studies of the hairpin ribozyme have revealed a distinct catalytic mechanism for this small RNA motif. Inner-sphere coordinated metal ions are not required, as the inert metal ion complex cobalt hexammine promotes catalysis. Detailed kinetic analyses have defined rates of individual steps in the catalytic cycle.
Nils G. Walter, John M. Burke
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Ribozymes: the hairpin and Varkud ribozymes are related.
Rivista di biologia, 2003The hairpin ribozyme of plant virusoids and the Varkud ribozyme from a retroplasmid of fungal mitochondria show notable similarities in sequence and secondary structure. Some more distant inter-relationships appear to exist between this pair, the viroid/virusoid hammerhead and the hepatitis delta ribozyme.
David Elder, Ray J. Harris
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Engineering of hairpin ribozyme variants for RNA recombination and splicing
Annals of the New York Academy of Sciences, 2019The hairpin ribozyme is a small, naturally occurring RNA that catalyzes the reversible cleavage of RNA substrates. Among the small endonucleolytic ribozymes, the hairpin ribozyme possesses the unique feature of the internal equilibrium between cleavage ...
R. Hieronymus, S. Müller
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Physical Chemistry, Chemical Physics - PCCP, 2018
Ribozymes catalyze the site-specific self-cleavage of intramolecular phosphodiester bonds. Initially thought to act as metalloenzymes, they are now known to be functional even in the absence of divalent metal ions and specific nucleobases directly ...
Narendra Kumar, D. Marx
semanticscholar +1 more source
Ribozymes catalyze the site-specific self-cleavage of intramolecular phosphodiester bonds. Initially thought to act as metalloenzymes, they are now known to be functional even in the absence of divalent metal ions and specific nucleobases directly ...
Narendra Kumar, D. Marx
semanticscholar +1 more source