Results 31 to 40 of about 8,461 (225)
RNA Back and Forth: Looking through Ribozyme and Viroid Motifs
Viruses, 2019 Current cellular facts allow us to follow the link from chemical to biochemical metabolites, from the ancient to the modern world. In this context, the “RNA world„ hypothesis proposes that early in the evolution of life, the ribozyme was ...
Marie-Christine Maurel +3 more
doaj +1 more source
BMC Biotechnology, 2011 Background The group I intron, a ribozyme that catalyzes its own splicing reactions in the absence of proteins in vitro, is a potential target for rational engineering and attracted our interest due to its potential utility in gene repair using trans ...
Takaku Hiroshi +2 more
doaj +1 more source
Mechanically probing the folding pathway of single RNA molecules [PDF]
, 2003 We study theoretically the denaturation of single RNA molecules by mechanical stretching, focusing on signatures of the (un)folding pathway in molecular fluctuations.
Banerjee +24 more
core +6 more sources
NLP Meets RNA: Unsupervised Embedding Learning for Ribozymes with Word2Vec [PDF]
arXiv, 2023 Ribozymes, RNA molecules with distinct 3D structures and catalytic activity, have widespread applications in synthetic biology and therapeutics. However, relatively little research has focused on leveraging deep learning to enhance our understanding of ribozymes.
arxiv
Intracellular RNA cleavage by the hairpin ribozyme [PDF]
Nucleic Acids Research, 1998 Studies involving ribozyme-directed inactivation of targeted RNA molecules have met with mixed success, making clear the importance of methods to measure and optimize ribozyme activity within cells. The interpretation of biochemical assays for determining ribozyme activity in the cellular environment have been complicated by recent results indicating ...
Attila A. Seyhan +2 more
openaire +3 more sources
Comprehensive sequence-to-function mapping of cofactor-dependent RNA catalysis in the glmS ribozyme. [PDF]
, 2020 Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such measurements and its
Andreasson, Johan OL +3 more
core
Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases [PDF]
, 2004 For two centuries, vaccination has been the dominating approach to develop prophylaxis against viral infections through immunological prevention. However, vaccines are not always possible to make, are ineffective for many viral infections, and also carry
Fang, Fang, Le Calvez, Hervé, Yu, Mang
core +3 more sources
Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit
Angewandte Chemie, EarlyView.A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo +7 more
wiley +2 more sources
CCR5 Targeted Cell Therapy for HIV and Prevention of Viral Escape
Viruses, 2015 Allogeneic transplantation with CCR5-delta 32 (CCR5-d32) homozygous stem cells in an HIV infected individual in 2008, led to a sustained virus control and probably eradication of HIV.
Gero Hütter +6 more
doaj +1 more source
Delineation of the Exact Transcription Termination Signal for Type 3 Polymerase III
Molecular Therapy: Nucleic Acids, 2018 Type 3 Pol III promoters such as U6 are widely used for expression of small RNAs, including short hairpin RNA for RNAi applications and guide RNA in CRISPR genome-editing platforms. RNA polymerase III uses a T-stretch as termination signal, but the exact
Zongliang Gao +2 more
doaj +1 more source