Results 51 to 60 of about 59,552 (223)

How RNA acts as a nuclease:some mechanistic comparisons in the nucleolytic ribozymes [PDF]

, 2017
Recent structural and mechanistic studies have shed considerable light on the catalytic mechanisms of nucleolytic ribozymes. The discovery of several new ribozymes in this class has now allowed comparisons to be made, and the beginnings of mechanistic ...
Lilley, David M. J.
core   +2 more sources

A triplex ribozyme expression system based on a single hairpin ribozyme. [PDF]

Oligonucleotides, 2008
Triplex ribozyme (RZ) configurations allow for the individual activity of trans-acting RZs in multiple expression cassettes (multiplex), thereby increasing target cleavage relative to conventionally expressed RZs. Although hairpin RZs have been advantageously compared to hammerhead RZs, their longer size and structural features complicated triplex ...
Aquino-Jarquin G, Benítez-Hess ML, DiPaolo JA, Alvarez-Salas LM.   +3 more
europepmc   +5 more sources

Force for ancient and recent life: viral and stem-loop RNA consortia promote life. [PDF]

, 2014
Lytic viruses were thought to kill the most numerous host (i.e., kill the winner). But persisting viruses/defectives can also protect against viruses, especially in a ubiquitous virosphere. In 1991, Yarmolinsky et al.
Villarreal, Luis P
core   +1 more source

Capturing the essence of folding and functions of biomolecules using Coarse-Grained Models

, 2011
The distances over which biological molecules and their complexes can function range from a few nanometres, in the case of folded structures, to millimetres, for example during chromosome organization. Describing phenomena that cover such diverse length,
A Dhar, A Elcock, A Elcock, A Grosberg, A Grosberg, A Minton, A Pisliakov, A Podtelezhnikov, A Rychkova, A Savelyev, A Vologodskii, AA Podtelezhnikov, B Messer, BJ Alder, C Bustamante, C Clementi, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, D Thirumalai, D Thirumalai, D Thirumalai, D Thirumalai, D Thirumalai, E Koculi, E Lieberman-Aiden, E O'Brien, E Shakhnovich, EP O'Brien, F Valle, G Lorimer, G Papoian, G Ziv, H Liu, H Ma, HX Zhou, I Tinoco Jr., J Chen, J Harms, J Karanicolas, J Straub, JD Honeycutt, JM Fernandez, JN Onuchic, KA Dill, M Levitt, M Mickler, M Strajbl, M Takano, ME Fisher, MJ Todd, MS Cheung, N Hirokawa, N Koga, N Toan, OK Dudko, P Weinkam, PB Moore, PC Whitford, Q Du, R Russell, R Tehver, R Tehver, RD Vale, RD Vale, RI Dima, RW Pastor, S Jun, S Jun, S Jun, S Kamerlin, S Kirkpatrick, S Moghaddam, SB Smith, SJ Chen, SJ Marrink, T Cloutier, T Cremer, T Kirkpatrick, T Veitshans, V Lubchenko, Z Liu, Z Xu   +89 more
core   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Classification of the nucleolytic ribozymes based upon catalytic mechanism [PDF]

, 2019
The nucleolytic ribozymes carry out site-specific RNA cleavage reactions by nucleophilic attack of the 2’-oxygen atom on the adjacent phosphorus with an acceleration of a million-fold or greater.
A Ferré-D'Amaré, A Forster, A Hampel, A Hampel, A Ke, A McLeod, A Perrotta, A Perrotta, A Ren, A Ren, A Roth, B Saville, B Saville, C Gaines, C Gaines, C Gaines, C Hutchins, D Eiler, D Klein, D Klein, F Jones, F Westheimer, G Slim, G Soukup, H van Tol, J Buzayan, J Cochrane, J Han, J Haseloff, J Murray, J Thomas, K Harris, K Young, L Hegg, L Kapinos, L Nguyen, L Zheng, M Canny, M Kuo, M Martick, M Oivanen, N Suslov, P Bevilacqua, P Rupert, R Breaker, S Das, S Kath-Schorr, S Koo, S Li, S Nakano, T Lee, T Wilson, T Wilson, T Wilson, T Wilson, W Winkler, Y Komatsu, Y Li, Y Liu, Y Liu, Z Weinberg, Z Weinberg   +61 more
core   +3 more sources

Rolling circle transcription of ribozymes from promoterless single-stranded DNA nanocircles in mammalian cells [Ribozimlerin, promotorsuz tek-iplikli DNA çemberlerinin rolling circle transkripsiyonu ile memeli hücrelerinde üretimi] [PDF]

Türk Biyokimya Dergisi, 2006
Self-processing hairpin ribozymes have been synthesized from promoterless singlestranded DNA circles (73 nt) within mammalian cells. Following lipid-mediated transient transfection, DNA circles were efficiently internalized by mouse L cells (OST7–1 ...
Attila A. Seyhan
doaj  

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Hairpin Ribozyme Structure and Dynamics

, 1997
Peer ...
Banerjee, Aloke Raj, Berzal-Herranz, Alfredo, Bond, J., Butcher, S., Esteban, José A., Heckman, Joyce, Sargueil, B., Walter, Nils, Burke, John M.   +8 more
openaire   +3 more sources

Mechanical unfolding of RNA hairpins

, 2005
Mechanical unfolding trajectories, generated by applying constant force in optical tweezer experiments, show that RNA hairpins and the P5abc subdomain of the group I intron unfold reversibly.
C. Hyeon, Camacho, D. Thirumalai, Fernandez, Gerland, Gerland, Klimov, Klimov, Klimov, Klimov, Koculi, Liphardt, Liphardt, Mathews, Misra, Onoa, R  disser, Thirumalai, Treiber, Walter   +19 more
core   +2 more sources