Results 51 to 60 of about 8,406 (222)
Role of tautomerism in RNA biochemistry [PDF]
, 2015 Heterocyclic nucleic acid bases and their analogs can adopt multiple tautomeric forms due to the presence of multiple solvent-exchangeable protons.
Essigmann, John M. +2 more
core +1 more source
Expanding the CRISPR toolbox in Culicine mosquitoes: in vitro validation of Pol III promoters [PDF]
, 2020 CRISPR–Cas9-based “gene drive” technologies have been proposed as a novel and effective means of controlling human diseases vectored by mosquitoes. However, more complex designs than those demonstrated to date—and an expanded molecular toolbox with which
Alphey, Luke +6 more
core +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian +3 more
wiley +1 more source
, 2006 Single molecule mechanical unfolding experiments are beginning to provide profiles of the complex energy landscape of biomolecules. In order to obtain reliable estimates of the energy landscape characteristics it is necessary to combine the experimental ...
Changbong Hyeon +9 more
core +1 more source
Classification of the nucleolytic ribozymes based upon catalytic mechanism [PDF]
, 2019 The nucleolytic ribozymes carry out site-specific RNA cleavage reactions by nucleophilic attack of the 2’-oxygen atom on the adjacent phosphorus with an acceleration of a million-fold or greater.
A Ferré-D'Amaré +61 more
core +3 more sources
Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 51-78, January 2026.ABSTRACT Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, experimental model building, and many other applications.
Rachael C. Kretsch +32 more
wiley +1 more source
, 2004 Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts.
Cedergren, Robert J. +4 more
core +1 more source
Lipid vesicles chaperone an encapsulated RNA aptamer. [PDF]
, 2018 The organization of molecules into cells is believed to have been critical for the emergence of living systems. Early protocells likely consisted of RNA functioning inside vesicles made of simple lipids.
Chen, Irene A +2 more
core +1 more source
Hairpin Ribozyme Structure and Dynamics
, 1997 A wide range of experimental methods have been used to explore the structure and function of the hairpin ribozyme. In vitro selection methods has provided comprehensive information on RNA secondary structure and the identity of essential bases within the two internal loops of the ribozyme-substrate complex.
Banerjee, Aloke Raj +8 more
openaire +2 more sources
Stem-cell-based gene therapy for HIV infection. [PDF]
, 2013 Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection.
Kitchen, Scott, Zhen, Anjie
core +2 more sources