Results 61 to 70 of about 8,461 (225)

Chain Length Determines the Folding Rates of RNA [PDF]

, 2012
We show that the folding rates (kFs) of RNA are determined by N, the number of nucleotides. By assuming that the distribution of free-energy barriers separating the folded and the unfolded states is Gaussian, which follows from central limit theorem ...
Hyeon, Changbong, Thirumalai, D.
core   +2 more sources

DNA Confined in Nanochannels: Hairpin Tightening by Entropic Depletion [PDF]

, 2006
A theory is presented of DNA hairpins enclosed in a nanochannel. A hairpin becomes constrained as it approaches the wall of a channel which leads to an entropic force causing the hairpin to tighten. The free energy of the hairpin computed in the classical limit is significantly larger than what one would expect.
arxiv   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Aptamers in oncology: a diagnostic perspective [PDF]

, 2008
Nucleic acid sequences can produce a wide variety of three-dimensional conformations. Some of these structural forms are able to interact with proteins and small molecules with high affinity and specificity.
Khan, Huma, Missailidis, Sotiris
core  

Classification of the nucleolytic ribozymes based upon catalytic mechanism [PDF]

, 2019
The nucleolytic ribozymes carry out site-specific RNA cleavage reactions by nucleophilic attack of the 2’-oxygen atom on the adjacent phosphorus with an acceleration of a million-fold or greater.
A Ferré-D'Amaré, A Forster, A Hampel, A Hampel, A Ke, A McLeod, A Perrotta, A Perrotta, A Ren, A Ren, A Roth, B Saville, B Saville, C Gaines, C Gaines, C Gaines, C Hutchins, D Eiler, D Klein, D Klein, F Jones, F Westheimer, G Slim, G Soukup, H van Tol, J Buzayan, J Cochrane, J Han, J Haseloff, J Murray, J Thomas, K Harris, K Young, L Hegg, L Kapinos, L Nguyen, L Zheng, M Canny, M Kuo, M Martick, M Oivanen, N Suslov, P Bevilacqua, P Rupert, R Breaker, S Das, S Kath-Schorr, S Koo, S Li, S Nakano, T Lee, T Wilson, T Wilson, T Wilson, T Wilson, W Winkler, Y Komatsu, Y Li, Y Liu, Y Liu, Z Weinberg, Z Weinberg   +61 more
core   +3 more sources

Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications

Small, EarlyView.
Nucleic acid‐modified nanoparticles act as functional hybrids for chemodynamic, photodynamic, photothermal, and gene therapy of cancer cells. These are exemplified with aptamer‐modified catalytic nanoparticles, photosensitizer‐oligonucleotide functionalized nanoparticles, drug‐loaded stimuli‐responsive nucleic acid‐caged nanoparticle carriers, and ...
Yunlong Qin, Xinghua Chen, Itamar Willner   +2 more
wiley   +1 more source

Progress toward curing HIV infection with hematopoietic cell transplantation. [PDF]

, 2015
HIV-1 infection afflicts more than 35 million people worldwide, according to 2014 estimates from the World Health Organization. For those individuals who have access to antiretroviral therapy, these drugs can effectively suppress, but not cure, HIV-1 ...
Armitage, Sue, Bakalinskaya, Milena, Burnett, John C, Clark, Pamela, Gragert, Loren, Gutman, Jonathan A, Kurtzberg, Joanne, Li, Haitang, Li, Shirley, Petz, Lawrence D, Querol, Sergio, Regan, Donna M, Rossi, John J, Shpall, Elizabeth J, Spellman, Stephen R, Tonai, Richard   +15 more
core   +1 more source

Rapid Amplification and Detection of Single‐Stranded Nucleic Acids for Point‐of‐Care Diagnosis

Small Methods, EarlyView.
A rapid, point‐of‐care nucleic acid test can greatly benefit healthcare system by providing timely diagnosis for effective treatment and patient management, as well as supporting diseases surveillance for emerging pandemic diseases. Recent advancements in nucleic acids technology have led to rapid assays for single‐stranded nucleic acids that can be ...
Jinglin Fu, Qiaochu Zhang, Shiming Liu, Derek Puyat, Akshay Shah, Alireza Ebrahimimojarad, Sung Won Oh   +6 more
wiley   +1 more source

Stem-cell-based gene therapy for HIV infection. [PDF]

, 2013
Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection.
Kitchen, Scott, Zhen, Anjie
core   +2 more sources