Results 61 to 70 of about 8,406 (222)
Advanced Engineering Materials, Volume 27, Issue 22, November 2025.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
In Vitro Selection of Adenine-dependent Hairpin Ribozymes [PDF]
Journal of Biological Chemistry, 2003 Adenine-dependent hairpin ribozymes were isolated by in vitro selection from a degenerated hairpin ribozyme population. Two new adenine-dependent ribozymes catalyze their own reversible cleavage in the presence of free adenine. Both aptamers have Mg(2+) requirements for adenine-assisted cleavage similar to the wild-type hairpin ribozyme.
Marc, Meli +2 more
openaire +2 more sources
RNA BiologySelf-cleaving ribozymes are versatile tools for synthetic biologists when it comes to controlling gene expression. Up to date, 12 different classes are known, and over the past decades more and more details about their structure, cleavage mechanisms and ...
Dennis Kläge +2 more
doaj +1 more source
Mechanical unfolding of RNA hairpins
, 2005 Mechanical unfolding trajectories, generated by applying constant force in optical tweezer experiments, show that RNA hairpins and the P5abc subdomain of the group I intron unfold reversibly.
C. Hyeon +19 more
core +2 more sources
Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems
Aggregate, Volume 6, Issue 11, November 2025.Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo +6 more
wiley +1 more source
Aptamers in oncology: a diagnostic perspective [PDF]
, 2008 Nucleic acid sequences can produce a wide variety of three-dimensional conformations. Some of these structural forms are able to interact with proteins and small molecules with high affinity and specificity.
Khan, Huma, Missailidis, Sotiris
core
Small, Volume 21, Issue 46, November 20, 2025.This review summarizes biomimetic design strategies for carbon‐based nanomaterials, including graphene oxide, carbon dots, and nanotubes, highlighting their tunable physicochemical properties for advanced biosensing and theranostic systems. Defined approaches such as DNA templating, peptide‐assisted assembly, and fluorescence switching are discussed ...
Marzieh Ramezani Farani +10 more
wiley +1 more source
Intracellular Immunization against SIVmacUtilizing a Hairpin Ribozyme
Virology, 1996 A hairpin ribozyme targeting the 3' LTR region (9456) of SIVmac238 was cloned into a murine retroviral vector. This target sequence is conserved among various SIV, as well as most HIV-2, strains. The ribozyme cassette is driven from a polymerase III promoter, that of the human tRNAval gene.
HEUSCH, MARINA +3 more
openaire +2 more sources
Progress toward curing HIV infection with hematopoietic cell transplantation. [PDF]
, 2015 HIV-1 infection afflicts more than 35 million people worldwide, according to 2014 estimates from the World Health Organization. For those individuals who have access to antiretroviral therapy, these drugs can effectively suppress, but not cure, HIV-1 ...
Armitage, Sue +15 more
core +1 more source
Small Structures, Volume 6, Issue 11, November 2025.The review comprehensively summarizes the binding behaviors and multidimensional applications of malachite green with diverse functional nucleic acids. By integrating structural mechanisms, comparative analysis, and application strategies across eight domains, it provides theoretical guidance and future perspectives for developing intelligent nucleic ...
Keren Chen +4 more
wiley +1 more source