Results 71 to 80 of about 59,552 (223)

Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications

Small, Volume 21, Issue 27, July 10, 2025.
Nucleic acid‐modified nanoparticles act as functional hybrids for chemodynamic, photodynamic, photothermal, and gene therapy of cancer cells. These are exemplified with aptamer‐modified catalytic nanoparticles, photosensitizer‐oligonucleotide functionalized nanoparticles, drug‐loaded stimuli‐responsive nucleic acid‐caged nanoparticle carriers, and ...
Yunlong Qin, Xinghua Chen, Itamar Willner   +2 more
wiley   +1 more source

Viroids: Survivors from the RNA World? [PDF]

, 2014
Because RNA can be a carrier of genetic information and a biocatalyst, there is a consensus that it emerged before DNA and proteins, which eventually assumed these roles and relegated RNA to intermediate functions.
Flores, Ricardo, Gago, Selma, Sanjuán, Rafael, Serra, Pedro   +3 more
core   +1 more source

A Programmed DNA Dynamic Assembly‐Guided Molecular Amplifier for Authentic Information Decryption

Advanced Science, Volume 12, Issue 22, June 12, 2025.
This study presents a DNA‐based constitutional dynamic network (CDN) with adaptive thresholds for secure information decryption. The system self‐calibrates output patterns, ensuring reproducibility and accuracy, and integrates molecular amplifiers for expanded message capacity and precise DNA sensing.
Ning Yang, Jie Zhou, Fengying Yuan, Yajuan Liu, Jia Zhang, Ying Zhuo, Yu Ouyang, Yaqin Chai, Pu Zhang, Ruo Yuan   +9 more
wiley   +1 more source

Self-assembly Controls Self-cleavage of HHR from ASBVd (−): a Combined SANS and Modeling Study [PDF]

, 2016
International audienceIn the Avocado Sunblotch Viroid (ASBVd: 249-nt) from the Avsunviroidae family, a symmetric rolling-circle replication operates through an autocatalytic mechanism mediated by hammerhead ribozymes (HHR) embedded in both polarity ...
Leclerc, Fabrice, Martel, Anne, Maurel, Marie-Christine, Vergne, Jacques, Zaccai, Giuseppe, Řìhovà, Martina   +5 more
core   +3 more sources

Influence of a 3′ Terminal Ribozyme on AgoshRNA Biogenesis and Activity

Molecular Therapy: Nucleic Acids, 2019
Short hairpin RNAs (shRNAs) can induce gene silencing via the RNA interference (RNAi) mechanism. We designed an alternative shRNA molecule with a relatively short base-paired stem that bypasses Dicer and instead is processed by the Argonaute 2 (Ago2 ...
Elena Herrera-Carrillo, Zongliang Gao, Ben Berkhout   +2 more
doaj  

Rapid Amplification and Detection of Single‐Stranded Nucleic Acids for Point‐of‐Care Diagnosis

Small Methods, Volume 9, Issue 6, June 20, 2025.
A rapid, point‐of‐care nucleic acid test can greatly benefit healthcare system by providing timely diagnosis for effective treatment and patient management, as well as supporting diseases surveillance for emerging pandemic diseases. Recent advancements in nucleic acids technology have led to rapid assays for single‐stranded nucleic acids that can be ...
Jinglin Fu, Qiaochu Zhang, Shiming Liu, Derek Puyat, Akshay Shah, Alireza Ebrahimimojarad, Sung Won Oh   +6 more
wiley   +1 more source

Searching for a DNAzyme version of the leadzyme [PDF]

, 2015
The final publication is available at Springer via http://dx.doi.org/10.1007/s00239-015-9702-zThe leadzyme refers to a small ribozyme that cleaves a RNA substrate in the presence of Pb2+. In an optimized form, the enzyme strand contains only two unpaired
Chen, Qingyun, Liu, Juewen, Saran, Runjhun   +2 more
core   +1 more source

Ribozyme-based insulator parts buffer synthetic circuits from genetic context [PDF]

, 2012
Synthetic genetic programs are built from circuits that integrate sensors and implement temporal control of gene expression. Transcriptional circuits are layered by using promoters to carry the signal between circuits. In other words, the output promoter
A Arkin, A Arkin, A Khvorova, AC Forster, AL Delcher, AM Walczak, B Munsky, B Munsky, B Munsky, B Wang, Brian Munsky, Brynne Stanton, C Hernández, C Lou, C Tan, CA Voigt, Christopher A Voigt, Chunbo Lou, D Del Vecchio, D Endy, D-K Ro, DT Gillespie, F Di Serio, HM Salis, J Beal, JA Nelson, JC Anderson, JC Anderson, JH Davis, JM Buzayan, JM Kaper, JM Pedraza, JR Kelly, K Clancy, K Temme, M Galdzicki, MB Elowitz, MJ Roossinck, PM Kim, R Grünberg, R Lutz, RP Shetty, S Hooshangi, T Ellis, TA Carrier, TS Gardner, VA Rhodius, Y Yokobayashi, Ying-Ja Chen   +48 more
core   +1 more source

Direct detection and quantification of microRNAs [PDF]

, 2009
The recent discovery of the potent regulatory nature of microRNAs (miRNAs), a relatively new class of approximately 22 nucleotide RNAs, has made them a primary focus in today’s biochemical and medical research.
Deo, Sapna K., Goulding, Ann M., Hunt, Eric A.   +2 more
core   +2 more sources

Engineering an optimized hypercompact CRISPR/Cas12j‐8 system for efficient genome editing in plants

Plant Biotechnology Journal, Volume 23, Issue 4, Page 1153-1164, April 2025.
Summary The Cas12j‐8 nuclease, derived from the type V CRISPR system, is approximately half the size of Cas9 and recognizes a 5′‐TTN‐3′ protospacer adjacent motif sequence, thus potentially having broad application in genome editing for crop improvement. However, its editing efficiency remains low in plants. In this study, we rationally engineered both
Shasha Bai, Xingyu Cao, Lizhe Hu, Danling Hu, Dongming Li, Yongwei Sun   +5 more
wiley   +1 more source