Results 81 to 90 of about 8,461 (225)
Physiologia Plantarum, Volume 177, Issue 2, March/April 2025.Abstract Viral infections are major contributors to crop yield loss and represent a significant threat to sustainable agriculture. Plants respond to virus attacks by activating sophisticated signalling cascades that initiate multiple defence mechanisms.
Kritika Shukla +4 more
wiley +1 more source
Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes [PDF]
, 2019 The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments short enough to be replicable by the ribozyme and if these fragments self-assemble into a functional ribozyme.
arxiv +1 more source
Development and applications of Coarse Grained models for RNA [PDF]
arXiv, 2014 In contrast to proteins much less attention has been focused on development of computational models for describing RNA molecules, which are being recognized as playing key roles in many cellular functions. Current atomically detailed force fields are not accurate enough to capture the properties of even simple nucleic acid constructs.
arxiv
Minimal models for proteins and RNA: From folding to function [PDF]
arXiv, 2008 We present a panoramic view of the utility of coarse-grained (CG) models to study folding and functions of proteins and RNA. Drawing largely on the methods developed in our group over the last twenty years, we describe a number of key applications ranging from folding of proteins with disulfide bonds to functions of molecular machines. After presenting
arxiv
Aptamer and DNAzyme Based Colorimetric Biosensors for Pathogen Detection
Angewandte Chemie, Volume 137, Issue 4, January 21, 2025.Pathogen detection is crucial for preventing and managing health risks. This review consolidates the selection of functional nucleic acids (FNAs) for pathogen detection and the development of cost‐effective, simple diagnostic applications. It focuses on integrating FNAs with gold nanoparticles, polydiacetylenes, protein enzymes, G‐quadruplexes, and ...
Rudi Liu +3 more
wiley +1 more source
Ribozymes: the characteristics and properties of catalytic RNAs [PDF]
, 2017 Ribozymes, or catalytic RNAs, were discovered a little more than 15 years ago. They are found in the organelles of plants and lower eukaryotes, in amphibians, in prokaryotes, in bacteriophages, and in viroids and satellite viruses that infect plants.
Tanner, N. Kyle
core
Salt Effects on the Thermodynamics of a Frameshifting RNA Pseudoknot under Tension
, 2016 Because of the potential link between -1 programmed ribosomal frameshifting and response of a pseudoknot (PK) RNA to force, a number of single molecule pulling experiments have been performed on PKs to decipher the mechanism of programmed ribosomal ...
Denesyuk, Natalia A. +2 more
core +1 more source
Visualising RNA folding dynamics in crowded environments and with single-molecule resolution [PDF]
, 2015 Cellular environments are highly crowded due to the presence of nucleic acids, proteins and other cellular organelles that can occupy between 20%- 40% of the total cellular volume.
Paudel, Bishnu
core +1 more source
Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1. [PDF]
, 2018 Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models.
An, Dong Sung +13 more
core +2 more sources
RNA self-splicing by engineered hairpin ribozyme variants. [PDF]
Nucleic Acids Res, 2022 Hieronymus R, Zhu J, Müller S.
europepmc +1 more source