Results 81 to 90 of about 59,552 (223)
Specificity of the Hairpin Ribozyme [PDF]
Journal of Biological Chemistry, 1999 Substrate sequence requirements of the hairpin ribozyme have been partially defined by both mutational and in vitro selection experiments. It was considered that the best targets were those that included the N downward arrowGUC sequence surrounding the cleavage site.
Mercedes Pérez-Ruiz +2 more
openaire +3 more sources
Large Phenotypic Enhancement of Structured Random RNA Pools. [PDF]
, 2020 Laboratory evolution of functional RNAs has applications in many areas of chemical and synthetic biology. In vitro selections critically depend on the presence of functional molecules, such as aptamers and ribozymes, in the starting sequence pools.
Chizzolini, Fabio +5 more
core
Rolling-circle replication of viroids, viroid-like satellite RNAs and hepatitis delta virus: variations on a theme [PDF]
, 1999 Viroids and viroid-like satellite RNAs from plants, and the human hepatitis delta virus (HDV) RNA share some properties that include small size, circularity and replication through a rolling-circle mechanism.
Flores, Ricardo +5 more
core +1 more source
Small, Volume 21, Issue 9, March 5, 2025.Microfluidic‐based directed evolution is a powerful tool for selection of biopolymers, however they struggle in transferability to intracellular environments. The “biomimetic equivalence” principle provides a versatile and practical framework for developing biopolymers that function effectively in cells using a cell‐free approach.
Andrew Brian Kinghorn +10 more
wiley +1 more source
Physiologia Plantarum, Volume 177, Issue 2, March/April 2025.Abstract Viral infections are major contributors to crop yield loss and represent a significant threat to sustainable agriculture. Plants respond to virus attacks by activating sophisticated signalling cascades that initiate multiple defence mechanisms.
Kritika Shukla +4 more
wiley +1 more source
, 2004 Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts.
Cedergren, Robert J. +4 more
core +1 more source
Molecular Mechanism of the site-specific self-cleavage of the RNA phosphodiester backbone by a Twister Ribozyme [PDF]
, 2017 Published as part of the special collection of articles derived from the 10th Congress on Electronic Structure: Principles and Applications (ESPA-2016).The catalytic activity of some classes of natural RNA, named as ribozymes, has been discovered ...
Bertrán, Juan +4 more
core +1 more source
Journal of Physical Chemistry B, 2010 The hairpin ribozyme is a prominent member of the group of small catalytic RNAs (RNA enzymes or ribozymes) because it does not require metal ions to achieve catalysis. Biochemical and structural data have implicated guanine 8 (G8) and adenine 38 (A38) as
V. Mlýnský +6 more
semanticscholar +1 more source
Ribozymes: the characteristics and properties of catalytic RNAs [PDF]
, 2017 Ribozymes, or catalytic RNAs, were discovered a little more than 15 years ago. They are found in the organelles of plants and lower eukaryotes, in amphibians, in prokaryotes, in bacteriophages, and in viroids and satellite viruses that infect plants.
Tanner, N. Kyle
core
Representation, searching and discovery of patterns of bases in complex RNA structures [PDF]
We describe a graph theoretic method designed to perform efficient searches for substructural patterns in nucleic acid structural coordinate databases using a simplified vectorial representation.
Artymiuk, P.J. +3 more
core +1 more source