Results 31 to 40 of about 3,140 (170)

Variant B cell receptor isotype functions differ in hairy cell leukemia with mutated BRAF and IGHV genes. [PDF]

PLoS ONE, 2014
A functional B-cell receptor (BCR) is critical for survival of normal B-cells, but whether it plays a comparable role in B-cell malignancy is as yet not fully delineated.
Nicola J Weston-Bell, Francesco Forconi, Hanneke C Kluin-Nelemans, Surinder S Sahota   +3 more
doaj   +1 more source

Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation

Frontiers in Immunology, 2020
Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell.
Ronit Mazor, Ira Pastan
doaj   +1 more source

Lymphocytosis, villi, and nucleoli: a variant of hairy cell leukemia [PDF]

Blood, 2016
![Figure][1] A 63-year-old woman being followed for splenomegaly presented with lymphocytosis (hemoglobin, 14 g/dL; neutrophils, 2.5 × 109/L; lymphocytes, 8.5 × 109/L; monocytes, 0.7 × 109/L; platelets, 200 × 109/L).
Tatiana Zarpelão Ferreira, Alex Freire Sandes   +1 more
openaire   +2 more sources

Plasma cell leukemia: A case series from South India with emphasis on rarer variants

Indian Journal of Medical and Paediatric Oncology, 2014
Plasma cell leukemia (PCL) is a rare and aggressive variant of plasma cell dyscrasia. They occur de novo (primary) or as a late manifestation of multiple myeloma (secondary). Patients present with anemia, thrombocytopenia, renal failure, organomegaly and
G Rajeswari, T Roshni Paul, Megha S Uppin, Shantveer G Uppin, D Raghunadha Rao, D Sree Bhushan Raju D, G Sadashindu   +6 more
doaj   +1 more source

Development of Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer: An Update

Biomolecules, 2020
Hepatocellular carcinoma (HCC) accounts for most liver cancers and represents one of the deadliest cancers in the world. Despite the global demand for liver cancer treatments, there remain few options available. The U.S. Food and Drug Administration (FDA)
Bryan D. Fleming, Mitchell Ho
doaj   +1 more source

A Review on Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Current Oncology, 2021
Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is a rare disease, representing
Elif Yilmaz, Arashpreet Chhina, Victor E. Nava, Anita Aggarwal   +3 more
doaj   +1 more source

Quantitative flow cytometric evaluation of CD200, CD123, CD43 and CD52 as a tool for the differential diagnosis of mature B-cell neoplasms

Revista Brasileira de Hematologia e Hemoterapia
Background Distinction between mature B-cell neoplasms can be difficult due to overlapping of immunologic features and clinical manifestations. This study investigated whether quantifying mean fluorescence intensity of four monoclonal antibodies in a ...
Elissandra Machado Arlindo, Natália Aydos Marcondes, Flavo Beno Fernandes, Gustavo Adolpho Moreira Faulhaber   +3 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source