Results 121 to 130 of about 582,180 (311)

Hydrophobin‐Coated Echogenic Microbubbles for Molecular Targeting of Tumor Cells

Advanced Science, EarlyView.
Echogenic microbubbles based on hydrophobin and corresponding fusion protein (HFBI‐domZ) are developed as contrast agents for cancer diagnostics. Hydrophobin provides high stabilization of encapsulated perfluoro‐n‐butane, and fusion proteins allow further versatile functionalization with antibodies. In‐vitro experiments indicate that these microbubbles
Hedar H. Al‐Terke, Grégory Beaune, Muhammad Junaid, Jani Seitsonen, Arja Paananen, Pierangelo Metrangolo, Jaakko V. I. Timonen, Jussi Joensuu, Robin H. A. Ras   +8 more
wiley   +1 more source

Changes of Trigonelline Biosynthesis under Nitrogenous Compounds in Hairy-root Culture of Iranian Fenugreek (Trigonella foenum-graecum L.)

Journal of Medicinal Plants, 2012
Background: Trigonelline is known as a valuable metabolite of alkaloids group with the therapeutic affects, especially on diabetes. Objective: In this study the effect of 3 levels of nitrogen compounds (2x, full, and half) of basic MS media including ...
Z Akbari, A Qaderi, S Kalate-jari, A Mehrafarin, H Naghdi Badi   +4 more
doaj  

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

Advanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai   +12 more
wiley   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Agrobacterium rhizogenes-Transformed Roots of Medicago truncatula for the Study of Nitrogen-Fixing and Endomycorrhizal Symbiotic Associations

Molecular Plant-Microbe Interactions, 2001
Medicago truncatula, a diploid autogamous legume, is currently being developed as a model plant for the study of root endosymbiotic associations, including nodulation and mycorrhizal colonization.
Aurélien Boisson-Dernier, Mireille Chabaud, Fernand Garcia, Guillaume Bécard, Charles Rosenberg, David G. Barker   +5 more
doaj   +1 more source

Transformation and Detection of Soybean Hairy Roots. [PDF]

Bio Protoc, 2023
Xu X, Yu TF, Ma J, Chen J, Zhou YB, Chen M, Chen ZY, Ma YZ, Xu ZS, Zhang ZA.   +9 more
europepmc   +1 more source

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development

Advanced Science, EarlyView.
Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang   +14 more
wiley   +1 more source

Programmable NIR Responsive Nanocomposite Enables Noninvasive Intratympanic Delivery of Dexamethasone to Reverse Cisplatin Induced Hearing Loss

Advanced Science, EarlyView.
In this study, saponin‐coated silica@gold nanocarriers responsive to NIR radiation is developed to enhance intratympanic drug delivery for cisplatin‐induced hearing loss (CIHL) treatment. The biocompatibility and oto‐protective properties are validated both in vitro and in vivo.
Rawand A. Mustafa, Jiali Wang, Mengzhao Xun, Jessica M. Rosenholm, Wuqing Wang, Yilai Shu, Hongbo Zhang   +6 more
wiley   +1 more source

Efecto de la aplicación de elicitores sobre la producción de 4b-hidroxiwithanólido E, en raíces transformadas de Physalis peruviana L

Universitas Scientiarum, 2009
Effect of elicitor application on the production of 4-b-hydroxy withanolide E by hairy roots of Physalis peruviana. Objectives: Tostudy the metabolite 4-b-hydroxy withanolide E production by the in vitro culture of golden berry (Physalis peruviana L ...
Yineth Piñeros-Castro, Ángela Otálvaro-álvarez, Mario Velásquez-Lozano   +2 more
doaj  

Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection

Advanced Science, EarlyView.
A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen, Hui Zhang, Jiayi Li, Xianmei Wei, Chenjie Yu, Yuanjin Zhao, Maoli Duan, Xiaoyun Qian, Xia Gao   +8 more
wiley   +1 more source