Results 141 to 150 of about 556,118 (330)

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Bryonolic Acid Production in Hairy Roots of Trichosanthes kirilowii MAX. var. japonica KITAM. Transformed with Agrobacterium rhizogenes and Its Cytotoxic Activity.

, 1994
Tadahiro Takeda, Toshikazu Kondo, Hiroaki Mizukami, Yasunari Ogihara   +3 more
openalex   +2 more sources

An efficient genetic transformation system mediated by Rhizobium rhizogenes in fruit trees based on the transgenic hairy root to shoot conversion

Plant Biotechnology Journal
Summary Genetic transformation is a critical tool for gene editing and genetic improvement of plants. Although many model plants and crops can be genetically manipulated, genetic transformation systems for fruit trees are either lacking or perform poorly.
Lin Liu, Jinghua Qu, Chunyan Wang, Miao Liu, Chunmeng Zhang, Xinyue Zhang, Cheng Guo, Changai Wu, Guodong Yang, Jinguang Huang, K. Yan, Huairui Shu, Chengchao Zheng, Shizhong Zhang   +13 more
semanticscholar   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Hairy Roots Formation in Four Solanaceae Species by Different Strains of Agrobacterium rhizogenes [PDF]

Journal of Medicinal Plants and By-products, 2014
Plants are the important sources of drugs. Secondary metabolites are responsible for therapeutic propertiesin plants. Three compounds including (-)-hyoscyamine, its racemate atropine, and scopolamine (hyoscine) are the most famous tropane alkaloids in ...
doaj  

Production of Two Isomers of Sphaeralcic Acid in Hairy Roots from Sphaeralcea angustifolia. [PDF]

Plants (Basel), 2023
Barrera K, González-Cortazar M, Reyes-Pérez R, Pérez-García D, Herrera-Ruiz M, Arellano-García J, Cruz-Sosa F, Nicasio-Torres P.   +7 more
europepmc   +1 more source

Effect of liquid flow on culture of red beet hairy roots in single column reactor.

, 1997
Yoshio Hitaka, Masahiro Kino‐oka, Masahito Taya, Setsuji Tone   +3 more
openalex   +2 more sources

Batch and Fed-Batch Production of Betalains by Red Beet (Beta vulgaris) Hairy Roots in a Bubble Column Reactor [PDF]

, 2007
Atanas Pavlov, Milen I. Georgiev, Thomas Bley   +2 more
openalex   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Evaluation of Salicylic Acid and Methyl Jasmonate as Elicitors in Phyllanthus acuminatus Hairy Roots by Non-Targeted Analysis Using High-Resolution Mass Spectrometry. [PDF]

Molecules, 2023
Benavides K, Sánchez-Kopper A, Jiménez-Quesada K, Perez R, Garro-Monge G.   +4 more
europepmc   +1 more source