Results 91 to 100 of about 15,156,055 (323)

PEPlife: A Repository of the Half-life of Peptides

Scientific Reports, 2016
Short half-life is one of the key challenges in the field of therapeutic peptides. Various studies have reported enhancement in the stability of peptides using methods like chemical modifications, D-amino acid substitution, cyclization, replacement of ...
Deepika Mathur, Satya Prakash, Priya Anand, Harpreet Kaur, P. Agrawal, A. Mehta, R. Kumar, Sandeep Singh, Gajendra P. Raghava   +8 more
semanticscholar   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Bioavailability and remineralization rates of sediment-derived dissolved organic carbon from a Baltic Sea depositional area

Frontiers in Marine Science
This pilot study investigated the bioavailability and remineralization kinetics of the sediment-derived dissolved organic carbon (DOC) from the Gdańsk Deep, a depositional area in the Baltic Sea.
Monika Lengier, Katarzyna Koziorowska-Makuch, Beata Szymczycha, Karol Kuliński   +3 more
doaj   +1 more source

Advances in Therapeutic Fc Engineering – Modulation of IgG-Associated Effector Functions and Serum Half-life

Frontiers in Immunology, 2016
Today, monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in cancer therapy especially for the patients with advanced or metastatic cancers.
A. Saxena, Donghui Wu
semanticscholar   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Methods for deriving the law of radioactive decay and the law of radiation absorption using the property of the exponent function when studying Physics in the system of secondary vocational education

Вестник Майкопского государственного технологического университета
In accordance with the educational standards of the Federal State Educational Standard for Secondary Professional Education, it is intended to familiarize students of professional educational organizations with the properties of radioactive radiation ...
D. B. Siyukhova, T. I. Demina
doaj   +1 more source

The half‐life of amitriptyline. [PDF]

British Journal of Clinical Pharmacology, 1978
H J, Rogers, P J, Morrison, I D, Bradbrook   +2 more
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Toxicological, Chemical, Social, and Economic Challenges Associated with PFAS and Replacement Aqueous Film-Forming Foams (AFFF)

Toxics
Poly- and perfluorinated alkyl substances (PFAS) are a group of chemicals that are widely used, prevalent in the environment, associated with several toxic effects, and often have long half-lives.
William S. Baldwin, Michael S. Bloom, Katy W. Chung, Subham Dasgupta, Marie E. DeLorenzo, Kelly J. Hunt, Peter B. Key, John L. Pearce, Kylie D. Rock, Philip Tanabe, Morgan A. Jacobellis, Melanie M. Garcia, Lisa J. Bain   +12 more
doaj   +1 more source

Citation analysis of the articles published in Scientific and Research Journal of Oceanography [PDF]

مجله علم‌سنجی کاسپین, 2018
Background and aim: The scientific journals are a valid method for communication of update information and a link among various fields of science through citation.
Masoumeh Dalvand, Homira Agah
doaj