Results 91 to 100 of about 9,553,129 (275)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Half-life (T_1/2) and other statistical parameters for fipronil dissipation in the cotton field conditions.

, 2017
Half-life (T1/2) and other statistical parameters for fipronil dissipation in the cotton field conditions.
Xiaohu Wu (1940080), Xingang Liu (312167), Jun Xu (45543), Yang Yu (4292), Pengqiang Du (3836539), Dongmei Wei (3836542), Fengshou Dong (1563970), Yongquan Zheng (398312)   +7 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Half-Life Extending Modifications of Peptide YY_3–36 Direct Receptor-Mediated Internalization

, 2019
Peptide YY3–36 (PYY3–36) is an endogenous ligand of the neuropeptide Y2 receptor (Y2R), on which it acts to reduce food intake. Chemically modified PYY3–36 analogues with extended half-lives are potential therapeutics for the treatment of obesity.
Esben M. Bech (4370779), Anette Kaiser (6412802), Annette G. Beck-Sickinger (92957), Kasper K. Sørensen, Kathrin Bellmann-Sickert, Nikos Hatzakis (7042895), Søren L. Pedersen, Knud J. Jensen (183822), Lisbeth Elster (7042892), Søren L. Pedersen (3599372), Nikos Hatzakis, Kasper K. Sørensen (697811), Søren S.-R. Nielsen, Esben M. Bech, Lisbeth Elster, Annette G. Beck-Sickinger, Søren S.-R. Nielsen (7042889), Knud J. Jensen, Kathrin Bellmann-Sickert (2204605), Anette Kaiser   +19 more
core   +1 more source

A Letter to Young and Future Leaders in Struggles for Health Rights and Social Justice [PDF]

Health and Human Rights, 2020
Alicia Ely Yamin
doaj  

Leveraging the Anuj transform: A novel approach to modeling population dynamics in interdisciplinary sciences

Al-Jabar
This study introduces the Anuj transform as an innovative tool for addressing population growth and decay problems. By applying the Anuj transform, we demonstrate its efficacy and practical value in solving these complex issues.
Hozan Hilmi, Shabaz Jalil, Hiwa Hussein Rahman, Bawar Mohammed Faraj   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Half Dome

, 2011
A imagem mostra a vista de Glacier Point, uma subida superior à um quilômetro acima do fundo do vale para Half Dome. As rochas graníticas que formam Half Dome representam o magma exposto por erosão profunda e glaciaçãoEnsino Fundamental Inicial::Meio ...
U.S. Geological Survey
core   +3 more sources