Results 71 to 80 of about 1,925,041 (282)

Increasing Temperature and Relative Humidity Accelerates Inactivation of SARS-CoV-2 on Surfaces

mSphere, 2020
Coronavirus disease 2019 (COVID-19) was first identified in China in late 2019 and is caused by newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Previous studies had reported the stability of SARS-CoV-2 in cell culture media
Jennifer Biryukov, Jeremy A. Boydston, Rebecca A. Dunning, John J. Yeager, Stewart Wood, Amy L. Reese, Allison Ferris, David Miller, Wade Weaver, Nathalie E. Zeitouni, Aaron Phillips, Denise Freeburger, Idris Hooper, Shanna Ratnesar-Shumate, Jason Yolitz, Melissa Krause, Gregory Williams, David G. Dawson, Artemas Herzog, Paul Dabisch, Victoria Wahl, Michael C. Hevey, Louis A. Altamura   +22 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Comment on "Precise half-life values for two-neutrino double beta decay"

, 2010
The results by A.S. Barabash [Phys. Rev. {\bf C 81}, 035501 (2010)] are shown to be incomplete. Tellurium data sets were reanalyzed using the best practices of ENSDF evaluations.
Pritychenko, B.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Toxicity, Half-Life and Antitumor Activity of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as Novel Antimitotic CYP1A1-Targeted Prodrugs in Female Mouse Models

Pharmaceutics
Background/Objectives: Chemoresistance of breast cancers (BCs) is a major impediment to current chemotherapeutics that urges the development of new drugs and new therapeutic approaches.
Atziri Corin Chavez Alvarez, Chahrazed Bouzriba, Vincent Ouellette, Mathieu Gagné-Boulet, Alexandre Patenaude, Sylvie Pilote, René C.-Gaudreault, Chantale Simard, Sébastien Fortin   +8 more
doaj   +1 more source

Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model

Journal of Investigative Surgery, 2017
Purpose/aim of the study: The pharmacokinetic (PK) parameters in animal models can help optimize novel candidate drugs prior to human trials. However, due to the complexity of pharmacokinetic experiments, their use is limited in academia.
Ioannis Christakis, Rebecca Scott, James Minnion, Joyceline Cuenco, Tricia Tan, Fausto Palazzo, Stephen Bloom   +6 more
doaj   +1 more source

Students' Beliefs About the Role of Atoms in Radioactive Decay and Half-life [PDF]

, 2007
Provides pedagogical insight concerning learners' pre-conceptions and misconceptions about radioactive decay The resource being annotated is: http://www.dlese.org/dds/catalog_ESA-000-000-000-035 ...
Lamont-Doherty Earth Observatory, Columbia University
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Bioavailability and remineralization rates of sediment-derived dissolved organic carbon from a Baltic Sea depositional area

Frontiers in Marine Science
This pilot study investigated the bioavailability and remineralization kinetics of the sediment-derived dissolved organic carbon (DOC) from the Gdańsk Deep, a depositional area in the Baltic Sea.
Monika Lengier, Katarzyna Koziorowska-Makuch, Beata Szymczycha, Karol Kuliński   +3 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source