Results 51 to 60 of about 15,156,055 (323)
In silico approaches for predicting the half-life of natural and modified peptides in blood
PLoS ONE, 2018 This paper describes a web server developed for designing therapeutic peptides with desired half-life in blood. In this study, we used 163 natural and 98 modified peptides whose half-life has been determined experimentally in mammalian blood, for ...
Deepika Mathur +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Chemical Strategies for Half-Life Extension of Biopharmaceuticals: Lipidation and Its Alternatives.
ACS Medicinal Chemistry Letters, 2018 Strategies for half-life extension are often required in the design of new biopharmaceuticals. This Viewpoint focuses on chemical moieties that convey protraction by albumin binding or by self-assembly to form larger structures, with GLP-1 and insulin as
Esben M. Bech +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
, 2006 We have measured the half-life of $^{14}$O, a superallowed $(0^{+} \to 0^{+})$ $β$ decay isotope. The $^{14}$O was produced by the $^{12}$C($^{3}$He,n)$^{14}$O reaction using a carbon aerogel target. A low-energy ion beam of $^{14}$O was mass separated and implanted in a thin beryllium foil.
Burke, Jason T. +4 more
openaire +4 more sources
Practical aspects of extended half-life products for the treatment of haemophilia
Therapeutic Advances in Hematology, 2018 Haemophilia A and haemophilia B are congenital X-linked bleeding disorders caused by deficiency of coagulation factor VIII (FVIII) and IX (FIX), respectively. The preferred treatment option for patients with haemophilia is replacement therapy.
T. Lambert +8 more
semanticscholar +1 more source
, 2021 Sensitivity as a measure of accuracy for the prediction of ectoderm and endomesoderm gene regulatory relations calculated with 5 different median mRNA half-life settings. For the Transcriptomic RNAseq data, 3hrs, 5hrs, 7hrs, 10hrs, 15hrs were tested. For
Doaa Altarawy (5586251) +6 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The Coxsackievirus and Adenovirus Receptor Has a Short Half-Life in Epithelial Cells
Pathogens, 2022 The coxsackievirus and adenovirus receptor (CAR) is an essential cellular protein that is involved in cell adhesion, cell signaling, and viral infection.
Poornima Kotha Lakshmi Narayan +8 more
doaj +1 more source