Results 41 to 50 of about 15,156,055 (323)
MedChemComm, 2019 Peptides and small protein scaffolds are gaining increasing interest as therapeutics. Similarly to full-length antibodies, they can bind a target with a high binding affinity and specificity while remaining small enough to diffuse into tissues.
Alessandro Zorzi +2 more
semanticscholar +1 more source
Injectables and Depots to Prolong Drug Action of Proteins and Peptides
Pharmaceutics, 2020 Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and ...
Nkiruka Ibeanu +7 more
doaj +1 more source
Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life
Frontiers in Immunology, 2019 Antibodies and Fc-fusion antibody-like proteins have become successful biologics developed for cancer treatment, passive immunity against infection, addiction, and autoimmune diseases.
K. Saunders
semanticscholar +1 more source
International Scientific Conference „Sustainable fruit and berry cultivation“ : the book of abstracts [PDF]
, 2021 19 November 2021 Polli Horticultural Research Centre Institute of Agricultural and Environmental Sciences Estonian University of Life Sciences.Dear conference participants and guests, As director of the Institute of Agricultural and Environmental ...
Estonian University of Life Sciences
core +1 more source
Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins.
Current pharmaceutical design, 2019 Peptides and proteins are two classes of molecules with attractive possibilities for therapeutic applications. However, the bottleneck for the therapeutic application of many peptides and proteins is their short halflives in vivo, typically just a few ...
Huanbo Tan +5 more
semanticscholar +1 more source
TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life
Life Science Alliance, 2019 This study demonstrates that the tetraspanins Tspan5 and Tspan15 which directly associate with the metalloprotease ADAM10 have an opposite impact on its endocytosis and half-life.
E. Eschenbrenner +8 more
semanticscholar +1 more source
Half-life measurement of 44Sc and 44mSc. [PDF]
, 2022 The half-lives of 44Sc and 44mSc were measured by following their decay rate using several measurement systems: two ionization chambers and three γ-spectrometry detectors with digital and/or analogue electronics.
Braccini, S. +19 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási +14 more
wiley +1 more source
Extending human IgG half-life using structure-guided design
mAbs, 2018 Engineering of antibodies for improved pharmacokinetics through enhanced binding to the neonatal Fc receptor (FcRn) has been demonstrated in transgenic mice, non-human primates and humans.
B. Booth +6 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters +17 more
wiley +1 more source