Results 21 to 30 of about 9,553,129 (275)

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

Pharmaceutics, 2020
Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and ...
Nkiruka Ibeanu, Raphael Egbu, Lesley Onyekuru, Hoda Javaheri, Peng Tee Khaw, Gareth R. Williams, Steve Brocchini, Sahar Awwad   +7 more
doaj   +1 more source

Dinâmica da comunidade arbórea de uma floresta semidecidual em Uberlândia, MG, Brasil Tree community dynamics in a semideciduous forest, in Uberlândia, Minas Gerais State, Brazil

Acta Botânica Brasílica, 2009
O objetivo do trabalho foi de verificar as mudanças ocorridas na comunidade arbórea em um intervalo de 14 anos. O estudo foi realizado em uma área de floresta semidecidual utilizando 50 parcelas de 10 m×10 m, onde foram amostradas todas as árvores com ...
Mariana Resende Silva, Glein Monteiro de Araújo   +1 more
doaj   +1 more source

An Omalizumab Biobetter Antibody With Improved Stability and Efficacy for the Treatment of Allergic Diseases

Frontiers in Immunology, 2020
The critical role of IgE in allergic diseases is well-documented and clinically proven. Omalizumab, a humanized anti-IgE antibody, was the first approved antibody for the treatment of allergic diseases. Nevertheless, omalizumab still has some limitations,
Peipei Liu, Peipei Liu, Zhongzong Pan, Chunyin Gu, Xiaodan Cao, Xiaowu Liu, Jianjian Zhang, Zheng Xiao, Xueping Wang, Haibing Guo, Dianwen Ju, Su-Jun Deng   +11 more
doaj   +1 more source

Modelos não lineares para a liberação de potássio de estercos animais em latossolos Non linear models to potassium release from animals manure in Latosols

Ciência Rural, 2012
Modelos não lineares são adequados para a descrição da liberação de nutrientes, uma vez que estimam quantidades de interesse prático e apresentam boa qualidade de ajuste.
Walmes Marques Zeviani, Carlos Alberto Silva, Waldete Japiassu de Oliveira Carneiro, Joel Augusto Muniz   +3 more
doaj   +1 more source

Utility of Feathers for Avian Influenza Virus Detection in Commercial Poultry

Pathogens, 2023
The present study evaluated the potential utility of feather samples for the convenient and accurate detection of avian influenza virus (AIV) in commercial poultry. Feather samples were obtained from AIV-negative commercial layer facilities in Iowa, USA.
Shahan Azeem, Baoqing Guo, Yuko Sato, Phillip C. Gauger, Anna Wolc, Kyoung-Jin Yoon   +5 more
doaj   +1 more source

The αSynuclein half-life conundrum

Neurobiology of Disease
αSynuclein (αSyn) misfolding and aggregation frequently precedes neuronal loss associated with Parkinson's Disease (PD) and other Synucleinopathies. The progressive buildup of pathological αSyn species results from alterations on αSyn gene and protein ...
Anna Masato, Luigi Bubacco
doaj   +1 more source

Free and Immobilized Microbial Culture–Mediated Crude Oil Degradation and Microbial Diversity Changes Through Taxonomic and Functional Markers in a Sandy Loam Soil

Frontiers in Environmental Science, 2022
Crude oil contamination of soil and water resources is a widespread issue. The present study evaluated the degradation of aliphatic hydrocarbons (C11–C36) in crude oil by 17 bacteria isolated from a crude oil–contaminated soil. The results suggested that
Ashish Khandelwal, Ashish Khandelwal, Ramya Sugavanam, B. Ramakrishnan, Anirban Dutta, Eldho Varghese, Lata Nain, Tirthankar Banerjee, Neera Singh   +8 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source