Results 31 to 40 of about 9,553,129 (275)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Half-life value evaluation.

, 2021
Sensitivity as a measure of accuracy for the prediction of ectoderm and endomesoderm gene regulatory relations calculated with 5 different median mRNA half-life settings. For the Transcriptomic RNAseq data, 3hrs, 5hrs, 7hrs, 10hrs, 15hrs were tested. For
Doaa Altarawy (5586251), Jingyi Zhang (741111), Sarah L. Tulin (11883691), Emily Najmulski (11883685), Lenwood S. Heath (10287135), Farhan Ibrahim (11883682), George Katholos (11883688)   +6 more
core   +1 more source

Half-Life of $^{14}$O

, 2006
We have measured the half-life of $^{14}$O, a superallowed $(0^{+} \to 0^{+})$ $β$ decay isotope. The $^{14}$O was produced by the $^{12}$C($^{3}$He,n)$^{14}$O reaction using a carbon aerogel target. A low-energy ion beam of $^{14}$O was mass separated and implanted in a thin beryllium foil.
Burke, Jason T., Vetter, Paul A., Freedman, Stuart J., Fujikawa, Brian K., Winter, Wesley T.   +4 more
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Coxsackievirus and Adenovirus Receptor Has a Short Half-Life in Epithelial Cells

Pathogens, 2022
The coxsackievirus and adenovirus receptor (CAR) is an essential cellular protein that is involved in cell adhesion, cell signaling, and viral infection.
Poornima Kotha Lakshmi Narayan, James M. Readler, Mahmoud S. Alghamri, Trisha L. Brockman, Ran Yan, Priyanka Sharma, Vladislav Snitsarev, Katherine J. D. A. Excoffon, Abimbola O. Kolawole   +8 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Synthesis and optimization of gemcitabine-loaded nanoparticles by using Box–Behnken design for treating prostate cancer: In vitro characterization and in vivo pharmacokinetic study

Green Processing and Synthesis
Gemcitabine (GC)-loaded chitosan (CS) nanoparticles were synthesized using the ionic gelation method. CS solution was prepared in glacial acetic solution 1% v/v under magnetic stirring for 2 h at 60˚C. The pH of resulting CS solutions was adjusted to 5 ±
Jamil Muhammad Anjum, Iqbal Furqan Muhammad, Sarwar Abdur Rehman, Iqbal Muhammad Omer, Arif Ahsan, Hadi Abas O., Gul Muhammad Tayyab, Ahmad Aftab, Munawar Nayla   +8 more
doaj   +1 more source

Comparison of Combined Dissipation Behaviors and Dietary Risk Assessments of Thiamethoxam, Bifenthrin, Dinotefuran, and Their Mixtures in Tea

Foods
In the tea-planting process, insecticides are commonly combined, potentially prolonging the pre-harvest interval and heightening the risk of dietary exposure.
Tiancai Wang, Yongzhong Qian, Jieqiong Wang, Xueyan Yin, Qifu Liang, Guangqin Liao, Xiabing Li, Jing Qiu, Yanyang Xu   +8 more
doaj   +1 more source