Results 61 to 70 of about 612,872 (266)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Exact Half-BPS Flux Solutions in M-theory III: Existence and rigidity of global solutions asymptotic to AdS4 x S7

, 2009
The BPS equations in M-theory for solutions with 16 residual supersymmetries, $SO(2,2)\times SO(4)\times SO(4)$ symmetry, and $AdS_4 \times S^7$ asymptotics, were reduced in [arXiv:0806.0605] to a linear first order partial differential equation on a ...
A. Donos, A. Erdelyi ed., A. Terras, D. Bak, Darya Krym, E. D'Hoker, E. D'Hoker, E. D'Hoker, E. D'Hoker, E. D'Hoker, E. D'Hoker, E. D'Hoker, E. D'Hoker, E. Witten, Eric D'Hoker, F. Oberhettinger, H. Lin, J. de Boer, J.M. Maldacena, John Estes, K. Skenderis, Michael Gutperle, O. Aharony, O. Lunin, S. Minwalla   +24 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A remark on the linearization technique in half-linear oscillation theory [PDF]

Opuscula Mathematica, 2006
We show that oscillatory properties of the half-linear second order differential equation \[(r(t)\Phi(x'))'+c(t)\Phi(x)=0,\qquad\Phi(x)=|x|^{p-2}x,\quad p\gt 1,\] can be investigated via oscillatory properties of a certain associated second order linear ...
Ondřej Došlý
doaj  

A note on the existence of solutions with prescribed asymptotic behavior for half-linear ordinary differential equations [PDF]

Mathematica Bohemica
The half-linear differential equation (|u'|^{\alpha}{\rm sgn} u')' = \alpha(\lambda^{\alpha+ 1} + b(t))|u|^{\alpha}{\rm sgn} u, \quad t \geq t_0, is considered, where $\alpha$ and $\lambda$ are positive constants and $b(t)$ is a real-valued ...
Manabu Naito
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Oscillation Theorems for Second-Order Half-Linear Advanced Dynamic Equations on Time Scales

International Journal of Differential Equations, 2011
This paper is concerned with the oscillatory behavior of the second-order half-linear advanced dynamic equation (𝑟(𝑡)(𝑥Δ(𝑡))𝛾)Δ+𝑝(𝑡)𝑥𝛾(𝑔(𝑡))=0 on an arbitrary time scale 𝕋 with sup 𝕋=∞, where 𝑔(𝑡)≥𝑡 and ∫∞𝑡𝑜(Δ𝑠/(𝑟1/𝛾(𝑠)))
Shuhong Tang, Tongxing Li, Ethiraju Thandapani   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Higher dimensional uniformisation and W-geometry

, 1994
We formulate the uniformisation problem underlying the geometry of W_n-gravity using the differential equation approach to W-algebras. We construct W_n-space (analogous to superspace in supersymmetry) as an (n-1) dimensional complex manifold using ...
Alvarez-Gaumé, Bilal, Bouwknegt, Das, de Boer, de Boer, de Boer, Drinfeld, Feher, Gerasimov, Gervais, Gervais, Govindarajan, Hawley, Hejhal, Hejhal, Hejhal, Hitchin, Hull, Hull, Itzykson, Jimbo, Jimbo, Kobayashi, Matsuo, Novikov, Simpson, Sotkov, Suresh Govindarajan, Wilczynski, Yoshida, Zamolodchikov, Zucchini   +32 more
core   +1 more source

Solutions of half-linear differential equations in the classes Gamma and Pi [PDF]

, 2016
We study asymptotic behavior of (all) positive solutions of the non-oscillatory half-linear differential equation of the form (r(t)|y'|^ {alpha-1} sgn y')'=p(t)|y|^{alpha-1}sgn y, where alpha>1 and r,p are positive continuous functions, with the ...
Rehak, Pavel, TADDEI, Valentina
core