Results 61 to 70 of about 1,460,019 (255)

Forced Oscillation of Second-Order Half-Linear Dynamic Equations on Time Scales

open access: yesAbstract and Applied Analysis, 2010
We will establish a new interval oscillation criterion for second-order half-linear dynamic equation (r(t)[xΔ(t)]α)Δ+p(t)xα(σ(t))=f(t) on a time scale T which is unbounded, which is a extension of the oscillation result for second order linear dynamic ...
Quanwen Lin, Baoguo Jia, Qiru Wang
doaj   +1 more source

Generalized discrete Riccati equation and oscillation of half-linear difference equations

open access: yesMathematical and Computer Modelling, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A note on the existence of solutions with prescribed asymptotic behavior for half-linear ordinary differential equations [PDF]

open access: yesMathematica Bohemica
The half-linear differential equation (|u'|^{\alpha}{\rm sgn} u')' = \alpha(\lambda^{\alpha+ 1} + b(t))|u|^{\alpha}{\rm sgn} u, \quad t \geq t_0, is considered, where $\alpha$ and $\lambda$ are positive constants and $b(t)$ is a real-valued ...
Manabu Naito
doaj   +1 more source

Variational properties and orbital stability of standing waves for NLS equation on a star graph

open access: yes, 2014
We study standing waves for a nonlinear Schr\"odinger equation on a star graph {$\mathcal{G}$} i.e. $N$ half-lines joined at a vertex. At the vertex an interaction occurs described by a boundary condition of delta type with strength $\alpha\leqslant 0 ...
Adami, R.   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Asymptotic Behavior of Solutions to Half‐Linear q‐Difference Equations [PDF]

open access: yesAbstract and Applied Analysis, 2010
We derive necessary and sufficient conditions for (some or all) positive solutions of the half‐linear q‐difference equation Dq(Φ(Dqy(t))) + p(t)Φ(y(qt)) = 0, t ∈ {qk : k ∈ ℕ0} with q > 1, Φ(u) = |u|α−1sgn u with α > 1, to behave like q‐regularly varying or q‐rapidly varying or q‐regularly bounded functions (that is, the ...
openaire   +4 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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