Results 31 to 40 of about 322,584 (266)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Development of high-performance heavy density concrete using different aggregates for gamma-ray shielding

HBRC Journal, 2015
The performance requirements of the concrete of containment structures are mainly radiological protection, structural integrity, durability, etc. For this purpose, high-performance heavy density concrete can be used. After extensive trials and errors, 15
Ahmed S. Ouda
doaj   +1 more source

Gamma Ray and FTIR Studies in Zinc Doped Lead Borate Glasses for Radiation Shielding Application [PDF]

Materials Research, 2018
Gamma ray shielding properties of borate glass samples containing oxides of lead and zinc are prepared by melt and quench technique and evaluated theoretically using XCOM computer software for gamma ray shielding properties.
Zakiyyu Ibrahim Takai, Rajinder Singh Kaundal, Mohd Kamarulzaki Mustafa, Saliza Asman, Aisha Idris, Yusuf Shehu, Jibrin Mohammad, Miftahu Gambo Idris, Mansur Said   +8 more
doaj   +1 more source

Correction of the Contribution of Scattered Photon Radiation to the Ionization Chamber Readings During X-Ray Radiation Quality Assessment

Приборы и методы измерений, 2022
Reduction of the systematic error when determining the characteristics of the reference X-ray radiation fields is an essential task according to the ISO 4037-1:2019 standard.
A. A. Zaharadniuk, K. G. Senkovsky, R. V. Lukashevich   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Understanding radiation shielding performance through a comparative study of half value layer in novel and preexisting silicate glasses

Nuclear Engineering and Technology
This study focuses on evaluating the PbO-SiO2-B2O3-Na2O glasses' radiation shielding ability against various previously tested materials to gain an in-depth understanding of the glass system's attenuation capabilities.
Albandari.W. Alrowaily, Aljawhara H. Almuqrin, M.I. Sayyed, B. Albarzan   +3 more
doaj   +1 more source

Pb-free Radiation Shielding Glass Using Coal Fly Ash

Journal of Mathematical and Fundamental Sciences, 2015
In this work, Pb-free shielding glass samples were prepared by the melt quenching technique using subbituminous fly ash (SFA) composed of xBi2O3 : (60-x)B2O3 : 10Na2O : 30SFA (where x = 10, 15, 20, 25, 30 and 35 by wt%). The samples were investigated for
Watcharin Rachniyom, Suparat Tuscharoen, Jakrapong Kaewkhao, Pumipat Pachana   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of $ \mathrm{Eu_2}\mathrm{O_3} $ and $ \mathrm{Er_2}\mathrm{O_3} $ on the gamma radiation shielding performance of $ \mathrm{B_2}\mathrm{O_3} $+CaO+ZnO+BaO+$ \mathrm{Eu_2}\mathrm{O_3} $ + $ \mathrm{Er_2}\mathrm{O_3} $ glass system [PDF]

Nuclear Technology and Radiation Protection
In this study, four rare earth-doped BaO-ZnO-CaO-$ \mathrm{B_2}\mathrm{O_3} $ glass samples were prepared using melt-quenching technique. The density of the glass was determined using Archimedes' method and found in range 3.28-3.72 $ gcm^{-3} $.
Almuqrin Aljawhara H., Alsubaie Jana Khalid, Elsafi Mohamed, Sayyed Mohammad I.   +3 more
doaj   +1 more source