Results 41 to 50 of about 418,007 (311)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correction of the Contribution of Scattered Photon Radiation to the Ionization Chamber Readings During X-Ray Radiation Quality Assessment

Приборы и методы измерений, 2022
Reduction of the systematic error when determining the characteristics of the reference X-ray radiation fields is an essential task according to the ISO 4037-1:2019 standard.
A. A. Zaharadniuk, K. G. Senkovsky, R. V. Lukashevich   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

6 layer BGA Half hole.JPG

, 2019
6 LAYER PCB only start at 160$,Specification:Copper thickness: inner layer 1OZ, outer layer 1/1OZBoard thickness:1.0mmMin hole size:0.25mmMin line width: 4milMin line spacing:4milsurface finish:ENIG 2u"Special: BGA,half holes,edge ...
Peter Li (6660044)
core   +1 more source

Performance characteristics of mobile MOSFET dosimeter for kilovoltage X-rays used in image guided radiotherapy

Journal of Medical Physics, 2015
The main objective of this study was to investigate the characteristics of metal oxide semiconductor field effect transistor (MOSFET) dosimeter for kilovoltage (kV) X-ray beams in order to perform the in vivo dosimetry during image guidance in ...
A Sathish Kumar, I Rabi Raja Singh, S D Sharma, B Paul Ravindran   +3 more
doaj   +1 more source

Impact of WO3 and BaO nanoparticles on the radiation shielding characteristics of polydimethylsiloxane composites

e-Polymers, 2023
In this study, we developed flexible composites using silicone rubber (SR) or polydimethylsiloxane as the matrix and WO3 and BaO nanoparticles as filler to analyze their radiation-shielding performance. The linear attenuation coefficient (LAC) values for
Alorain Dalal A., Almuqrin Aljawhara H., Sayyed M. I., Elsafi Mohamed   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The effect of replacing sand by iron slag on physical, mechanical and radiological properties of cement mortar

HBRC Journal, 2017
In the present study, the effects of replacing sand by high percentages of basic-oxygen furnace slag on the compressive strength, bulk density and gamma ray radiation shielding properties of mortar have been investigated.
Ahmed S. Ouda, Hamdy A. Abdel-Gawwad
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Development of high-performance heavy density concrete using different aggregates for gamma-ray shielding

HBRC Journal, 2015
The performance requirements of the concrete of containment structures are mainly radiological protection, structural integrity, durability, etc. For this purpose, high-performance heavy density concrete can be used. After extensive trials and errors, 15
Ahmed S. Ouda
doaj   +1 more source