Results 51 to 60 of about 418,007 (311)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Influence of boundary layer transition on the trajectory optimisation of a reusable launch vehicle

, 2014
Based on flight experience from the Space Shuttle programme, it is well known that mis-prediction of the effects of boundary layer transition represents one of the highest technical risks when designing a Reusable Launch Vehicle.
Edmondo Minisci, Fabrizio Pescetelli, Richard E. Brown, Minisci, Edmondo, Wuilbercq, Romain, Romain Wuilbercq, Pescetelli, Fabrizio, Brown, Richard   +7 more
core   +1 more source

Determination of the Tenth and Half Value Layer Thickness of Concretes with Different Densities [PDF]

, 2020
Half value layer (HVL) is the most frequently used quantitative factor for describing both the penetrating ability of specific radiations and the penetration through specific objects.
A Akkaş
core  

Understanding radiation shielding performance through a comparative study of half value layer in novel and preexisting silicate glasses

Nuclear Engineering and Technology
This study focuses on evaluating the PbO-SiO2-B2O3-Na2O glasses' radiation shielding ability against various previously tested materials to gain an in-depth understanding of the glass system's attenuation capabilities.
Albandari.W. Alrowaily, Aljawhara H. Almuqrin, M.I. Sayyed, B. Albarzan   +3 more
doaj   +1 more source

Investigation on radiation shielding parameters of cerrobend alloys

Nuclear Engineering and Technology, 2017
In this study, to determine the most effective alloy for shielding against gamma-rays, the gamma-ray shielding parameters of six types of cerrobend alloys have been investigated.
Borhan Tellili, Youssef Elmahroug, Chedly Souga   +2 more
doaj   +1 more source

Measurement and Research of Intrinsic Filtering of X-Ray Optical Machine

Journal of Isotopes, 2021
The thickness of the inherent filter layer is one of the important performance parameters of the X-ray reference radiation device, and it needs to be quantitatively measured. This research is based on the new version of ISO 4037-1 standard specification,
HANG Zhongbin;LIU Chuanfeng;LIU Yuntao;WEI Kexin;SONG Mingzhe;WANG Hongyu
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A numerical model study of the stratocumulus-topped marine boundary layer [PDF]

, 1999
A one-dimensional model with second order turbulence closure has been developed and used to investigate processes in the cloud-topped marine atmospheric boundary layer.
Kent, E.C.
core  

The effects of water and microstructure on the performance of polymer electrolyte fuel cells [PDF]

, 2006
n this paper, we present a comprehensive non-isothermal, one-dimensional model of the cathode side of a Polymer Electrolyte Fuel Cell. We explicitly include the catalyst layer, gas diffusion layer and the membrane.
Shah, A., Promislow, K., Young, A., Yi, S., Gervais, W., Li, J., Kim, G.S.   +6 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source