Results 71 to 80 of about 1,514,488 (302)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A possible explanation of the dependence of the Q-value on the accelerating gradient for the LEP superconducting cavities [PDF]

, 1996
A mechanism to explain the decrease of the Q-value at high field in superconducting cavities for accelerator application is proposed and compared with experiment.
Weingarten, Wolfgang
core  

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Pembuatan Model Uji Nilai Tebal Paruh (Hvl) Pesawat Konvensional Sinar-x Menggunakan Pengolahan Citra Digital [PDF]

, 2013
Designed of software application half value layer (HVL) which uses digital image processing has been use measurement HVL of X-ray conventional that is designed by using Borland Delphi 7.0 program. The system used as a simple tool for quality control (QC)
Maulana, H. (Hayat), Suryono, S. (Suryono)   +1 more
core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Radiation shielding properties of selenium-based lead borate PbO-SeO2-B2O3 glass for X-ray and gamma radiation

Physics Open
The radiation shielding properties of selenium-based lead borate glass systems xSeO2 + (25-x) B2O3 + 75PbO (x = 0, 0.2, 0.4, 0.6) were investigated using the MCNPx simulation and the Phy-x/PSD program in the energy range of 0.015–15 MeV.
Suleman Muhammad, Seema Mukamil, Iltaf Muhammad, Sang Peng, Kunning Niu, Zan Zhang, Yongsheng Li   +6 more
doaj   +1 more source

An approach for solving the boundary free edge difficulties in SPH modelling: application to a viscous accretion disc in close binaries

, 2011
In this work, we propose a SPH interpolating Kernel reformulation suitable also to treat free edge boundaries in the computational domain. Application to both inviscid and viscous stationary low compressibility accretion disc models in Close Binaries (CB)
Belvedere, Benz, Bonet, Bonet, Boris, Costa, Drimmel, Evrard, Feldman, Flebbe, Flebbe, Frank, Fulbright, G. Lanzafame, Hernquist, Imaeda, Kaisig, Katz, Lanzafame, Lanzafame, Lanzafame, Lanzafame, Lanzafame, Lanzafame, Lanzafame, Lanzafame, Lanzafame, Lasota, Lattanzio, Liu, Lubow, Meglicki, Miyama, Molteni, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Morris, Murray, Nelson, Nelson, Okazaki, Owen, Pringle, Savonije, Sawada, Sawada, Shakura, Shakura, Shakura, Shapiro, Sod, Speith, Speith, Springel, Spruit, Vaughan   +60 more
core   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Preparation and structural properties of thin films and multilayers of the Heusler compounds Cu2MnAl, Co2MnSn, Co2MnSi and Co2MnGe [PDF]

, 2002
We report on the preparation of thin films and multilayers of the intermetallic Heusler compound CuMnAl, Co2MnSn, Co2MnSi and Co2MnGe by rf-sputtering on MgO and Al2O3 substrates.
A Bergmann, Ambrose, Bacon, Bruno, Caballero, de Groot, Dieny, Geiersbach, Gijs, Ishida, Ishida, K Westerholt, Kabani, Kautzky, Kübler, Mancoff, Moodera, Orgassa, Paratt, Park, Raphael, Robinson, Schwarz, Soltys, Taylor, U Geiersbach, Webster, Westerholt, Zabel   +28 more
core   +1 more source

Prevalence of Systemic Lupus Erythematosus in Australia, 2010–2022: A Population‐Based Study Using Linked National Administrative Health Data

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a heterogenous inflammatory condition with widely varying global prevalence estimates. The frequency of SLE in the general population of Australia has been reported to be notably lower than contemporary estimates in countries such as the United States or United Kingdom, at 19 to 39 per 100,000 as opposed ...
Lucinda Roper, Rachel Black, Joanna Tieu, Winnie Chen, Matthew Parker, Catherine Hill, Natasha Nassar, Mandana Nikpour   +7 more
wiley   +1 more source