Results 131 to 140 of about 43,711 (206)

Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025

Movement Disorders, Volume 41, Issue 9, Page 2267-2277, September 2026.
Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova, Jenny Townhill, Juliana Bronzova, Viktoria Andreeva, Swati Sathe, Cristina Sampaio   +5 more
wiley   +1 more source

The impact of the CYP2D6 polymorphism on haloperidol pharmacoldnetics and on the outcome of haloperidol treatment

, 2002
Objectives: The genetically polymorphic enzyme cytochrome P450 (CYP) 2D6 contributes to the biotransformation of the antipsychotic drug haloperidol.
Schmider, J., Muller-Oerlinghausen, B., Kirchheiner, Julia, Roots, Ivar, Walter, S., Brockmoeller, Juergen, Sachse, C.   +6 more
core   +1 more source

Digital and Biomarker‐Based Monitoring for Schizophrenia‐Treatment Adherence

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
Monitoring technologies integrated with artificial intelligence can enable personalized care, improved adherence, and reduced relapses among psychotic patients. ABSTRACT Background Nonadherence to antipsychotics affects nearly half of patients with schizophrenia, leading to rehospitalization, suicidality, and reduced quality of life.
Samuel Inshutiyimana, Kush Rajeshbhai Rana, Michael Matiop Aleu, Naomi Bwalya, Bonaventure Nsengimana, Onesmas Kipkurui   +5 more
wiley   +1 more source

Possible Contribution of Multiple Sclerosis Pathology to Treatment‐Resistant Schizophrenia: A Case Study

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
A case of multiple sclerosis detected by brain MRI during evaluation for modified electroconvulsive therapy in the long‐term course of schizophrenia. This case discusses the clinical overlap between multiple sclerosis pathology and treatment‐resistant schizophrenia. ABSTRACT Multiple sclerosis (MS) can present with neurological and psychiatric symptoms
Sho Miura, Atsuko Nagaoka, Mizuki Hino, Risa Shishido, Masataka Hatano, Yuto Hosogai, Kazusa Miyahara, Yuta Oba, Kimihiko Kaneko, Yasuto Kunii, Hiroaki Tomita   +10 more
wiley   +1 more source

A case of tic improvement following tipepidine administration in a boy with Tourette syndrome comorbid with attention‐deficit/hyperactivity disorder and autism spectrum disorder

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Background Tourette Syndrome (TS) is defined by motor and vocal tics that begin in childhood and persist for over a year. TS causes difficulties in daily life and lowers self‐esteem, yet pharmacological treatment options for TS remain limited.
Masumi Tachibana, Tsuyoshi Sasaki
wiley   +1 more source

Cytoscape graph for QTPROL-haloperidol.

, 2012
The results of the ADR-S workflow can be visualized as a graph in which the nodes are proteins, compounds and clinical events. A: Detail of the network depicting the haloperidol targets, the proteins associated with QTPROL and the connection between them.
María del Carmen Carrascosa (173612), Pedro Lopes (376960), José L. Oliveira (173628), Anna Bauer-Mehren (173597), Ferran Sanz (89706), Jan A. Kors (173657), Paul Avillach (173608), Bharat Singh (173621), Ricard Garcia-Serna (173615), Scott Boyer (173647), Erik M. van Mullingen (173602), Ernst Ahlberg Helgee (173638), Gayo Diallo (173632), Janet Piñero (173618), Jordi Mestres (168498), Laura I. Furlong (173662)   +15 more
core   +1 more source

Substandard and Falsified Medicines, Regulatory Capacity and Public Health: A Narrative Review With a Focus on Africa

Public Health Challenges, Volume 5, Issue 3, September 2026.
Weak medicines regulation in Africa enables the circulation of substandard and falsified medicines, undermining treatment outcomes, accelerating antimicrobial resistance and eroding public trust. This narrative review synthesised 38 studies from 2000 to 2025, highlighting regulatory gaps, public health harms and regional disparities.
Ahmed Vandy, Nancy Oluwakemi Samai, Onome Thomas Abiri, Michael Lahai, Fawzi Thomas, Tamba Buffa, Sheku Mansaray, Alvin Turay, Augustus Osborne   +8 more
wiley   +1 more source

The effect of haloperidol’s perioperative application on postoperative delirium in elderly patients: a systematic review and meta-analysis

BMC Anesthesiology
Objectives To systematically review the evidence about the effect of haloperidol on postoperative delirium in elderly patients. Methods PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure were used to find concerned studies ...
Meinv Liu, Jie Su, Bei Wang, Dongdong Yu, Jianli Li, Xinyu Cao   +5 more
doaj   +1 more source

Visible‐light‐promoted catalyst‐free benzylic C‐H oxidation using molecular oxygen as a green oxidant

Smart Molecules, Volume 4, Issue 3, September 2026.
A green and simple photo‐oxygenation of benzylic C‐H bond with molecular oxygen was developed for the preparation of a series of carbonyl compounds. The straightforward C‐H carbonylation strategy features catalyst‐ and additive‐free reaction conditions, only oxygen as a green oxidant, broad scope and scalable, and the simple‐operation nature.
Jianing Li, Suwen Wang, Huinan Sun, Zhunchao Liu, Xiangmin Tian, Qilei Liu, Qingwei Meng   +6 more
wiley   +1 more source

A call for action: Closing the evidence gap in management of stimulant‐induced psychosis

Addiction, Volume 121, Issue 9, Page 2275-2283, September 2026.
Abstract Background Stimulant‐induced psychosis (StIP) is emerging as one of most pressing health challenges. Over the past two decades, stimulant‐related harms and psychiatric care demands have risen sharply. Individuals with StIP often present with severe agitation and high suicide risk, and up to half progress to chronic psychotic illness within two
Anne Bouthillier, Heidar Sharafi, Adam Bisaga, Didier Jutras‐Aswad   +3 more
wiley   +1 more source